Results 61 to 70 of about 918,890 (256)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Bistable Biorders: A Sequential Domain Theory [PDF]
Logical Methods in Computer Science, 2007 We give a simple order-theoretic construction of a Cartesian closed category of sequential functions. It is based on bistable biorders, which are sets with a partial order -- the extensional order -- and a bistable coherence, which captures equivalence ...
James Laird
doaj +1 more source
Relative directed homotopy theory of partially ordered spaces [PDF]
, 2006 Algebraic topological methods have been used successfully in concurrency theory, the domain of theoretical computer science that deals with distributed computing. L. Fajstrup, E. Goubault, and M. Raussen have introduced partially ordered spaces (pospaces)
Kahl, Thomas
core +3 more sources
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Electromechanical Analysis of Flexoelectric Nanosensors Based on Nonlocal Elasticity Theory
Micromachines, 2020 Flexoelectric materials have played an increasingly vital role in nanoscale sensors, actuators, and energy harvesters due to their scaling effects. In this paper, the nonlocal effects on flexoelectric nanosensors are considered in order to investigate ...
Yaxuan Su, Zhidong Zhou
doaj +1 more source
Equivariant rational homotopy theory as a closed model category
Journal of Pure and Applied Algebra, 1998 Using the result of \textit{D. A. Edwards} and \textit{H. M. Hastings} [Čech and Steenrod homotopy theories with applications to geometric topology, Lect. Notes Math. 542 (1976; Zbl 0334.55001)] the author proves that a closed model structure on a category \({\mathcal C}\) can be extended to the functor category \({\mathcal I}\)-\({\mathcal C}\) where ...
openaire +2 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
OWNC: Open-World Node Classification on Graphs with a Dual-Embedding Interaction Framework
MathematicsTraditional node classification is typically conducted in a closed-world setting, where all labels are known during training, enabling graph neural network methods to achieve high performance.
Yuli Chen, Chun Wang
doaj +1 more source
Semi-closed Input-output Model with Semi-endogenous Consumption:Case Study for Iran [PDF]
پژوهشهای اقتصادی, 2023 Aim and Introduction In the conventional Input-Output model, all final demand components including household consumption, government expenditures, capital accumulation and exports are considered as exogenous variables.
zeinab yazdani charati +2 more
doaj
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source