Results 151 to 160 of about 616 (224)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Hardware Architecture of Tree Structure for Real-time Progressive Sequential Pattern Mining
, 2007 傳統的循序樣式探勘演算法需要龐大的計算時間。當面臨累進式資料庫探勘時所需要的時間更多。在本論文中，我們設計了一種硬體的樹狀結構，用來解決累進式循序樣式探勘的問題。我們的演算法簡稱為HATS，運用樹狀結構代表每一個序列中的循序元素。透過管線設計，HATS可以高效率的產生循序元素。我們透過軟硬體共同設計，在可規劃邏輯閘陣列上，完成實體電路的設計與驗証。我們的實驗結果也顯示HATS不僅在隨機的測試資料中，明顯地比現有的所有循序樣式探勘演算法快速；並且對於一個在無線閘道的實際應用上表現優異 ...
Chen, Bo-Han, 陳伯翰
core
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
, 2012 : Discovering patterns in a sequence is an important aspect of data mining. One popular choice of such patterns are episodes, patterns in sequential data describing events that often occur in the vicinity of each other.
Cule, Boris, Tatti, Nikolaj
core
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
The Value of Information in Salmon Farming: Harvesting the Right Fish to the Right Time
Research regarding management practice in fish farming has traditionally focused on two topics: production planning and forecasting of prices. This article combine these two areas of research, and illustrate how information of price patterns can change ...
Guttormsen, Atle G., Forsberg, Odd Inge
core
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source