Results 131 to 140 of about 4,031,702 (245)
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Mining Maximal Sequential Patterns in Protein Databases
, 2007 蛋白質序列中的序列樣式，和蛋白質所執行的功能有著密不可分的關係。因此，如何從蛋白質序列資料庫中，透過系統化的方法，探勘出重要的序列樣式，已成為一個相當重要的研究課題。 針對此一課題，本論文提出了一個以字尾樹(suffix tree)為基礎的演算法。演算法中的所有過程，包括探勘序列樣式中的封閉性高頻子字串(closed frequent substring)，將封閉性子字串組成最大高頻序列樣式(maximal frequent sequential pattern)，以及調整序列樣式中子字串間的間隔 ...
凌宇, Ling, Yu
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Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Biophysical modeling of thalamocortical circuit dynamics: species-specific insights into neural synchrony, sleep spindles, and circuit mechanisms. [PDF]
Sleep AdvZikopoulos B +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Open-skill vs. closed-skill sports and executive function in children and adolescents: a mini review of mechanisms and moderating factors. [PDF]
Front PsycholZhang H, Wei W, Zhang W.
europepmc +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Geometry-Mechanics Compatibility Enables Interpretable Inverse Design of Non-Rigid Origami. [PDF]
Research (Wash D C)Sun Y +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
PRUNING DISCOVERED SEQUENTIAL PATTERNS USING MINIMUM IMPROVEMENT THRESHOLD
, 2008 . Discovery of sequential patterns is an important data mining problem with numerous applications. Sequential patterns are subsequences frequently occurring in a database of sequences of sets of items.
Marek Wojciechowski +2 more
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