Results 111 to 120 of about 4,031,702 (245)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Detection of Trends of Internet Traffic Using Sequential Patterns
We propose a new method of possible trend detection in the internet traffic by using sequential pattern analysis. The main steps of this method, such as the template pattern discovery in time-series data and pattern comparison and matching for sequential
Lauks, Gunārs, Jeļinskis, Jans
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Mining closed high-utility frequent sequential patterns based on a genetic algorithm
Mining Frequent Closed High-Utility Sequential Patterns (FCHUSPs) is an important problem in data mining, with many practical applications such as customer behavior analysis, supply chain optimization, and marketing.
Anh Duy Tran, Nguyen Le
core +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
An Obstruction-Check Approach to Mining Closed Sequential Patterns in Data Streams
, 2010 Online mining sequential patterns over data streams is an important problem in data mining. There are many applications of using sequential patterns in data streams, such as market analysis, network security, sensor networks and web track- ing.
Chin, Tsz-lin
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Incremental mining of temporal patterns in interval-based database
, 2016 In several real-life applications, sequence databases, in general, are updated incrementally with time. Some discovered sequential patterns may be invalidated and some new ones may be introduced by the evolution of the database.
Hui, Lin; Chen, Yi-Cheng; Weng, Julia Tzu-Ya; Lee, Suh-Yin
core +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
CASM: searching context-aware sequential patterns iteratively [PDF]
, 2011 Many applications are interested in mining context-aware sequential patterns such as opinions, common navigation patterns, and product recommendations.
Zhong, Hengzhi
core