Results 101 to 110 of about 4,031,702 (245)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Discovering Closed Frequent Patterns in Moving Trajectory Database
, 2012 The increasing availability of tracking devices bring larger amounts of trajectories representing people's moving location histories. In this paper, we aimed to mine closed frequent patterns in moving trajectory database.
Wang L(王亮) +3 more
core
Mining closed partially ordered patterns, a new optimized algorithm
, 2015 International audienceNowadays, sequence databases are available in several domains with increasing sizes. Exploring such databases with new pattern mining approaches involving new data structures is thus important.
Braud, Agnès +4 more
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
An Algorithm for Mining Strong Negative Fuzzy Sequential Patterns
, 2013 Many methods have been proposed for mining fuzzy sequential patterns. However, most of conventional methods only consider the occurrences of fuzzy itemsets in sequences.
Lin, Nancy P.; Hao, Wei-hua, Chen, Hung-jen; Chang, Chung-i; Chueh, Hao-en
core
Finding maximal sequential patterns in text document collections and single documents [PDF]
, 2010 In this paper, two algorithms for discovering all the Maximal Sequential Patterns (MSP) in a document collection and in a single document are presented. The proposed algorithms follow the “pattern-growth strategy” where small frequent sequences are found
JESUS ARIEL CARRASCO OCHOA +2 more
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
COBRA: Closed Sequential Pattern Mining Using Bi-phase Reduction Approach
, 2008 . In this work, we study the problem of closed sequential pattern mining. We propose a novel approach which extends a frequent sequence with closed itemsets instead of single items.
Kuo-yu Huang +3 more
core