Results 121 to 130 of about 157,330 (294)
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Approaches for Pattern Discovery Using Sequential Data Mining
, 2012 In this chapter we first introduce sequence data. We then discuss different approaches for mining of patterns from sequence data, studied in literature.
Manish Gupta, Jiawei Han
core +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Mining Closed Patterns in Multi-sequence Time-series Databases
, 2007 序列樣式分析已經被廣泛地應用在許多領域上，且已經有許多尋找序列樣式的方法被提出。但是目前所提出的方法只考慮每筆交易只含有一條序列，並沒有考慮每筆交易含有多序列的情形，也沒有考慮到項目集合間的時間間隔，因此，這篇論文將探討尋找多序列樣式之資料探勘。在本篇論文中我們提出一個有效率的探勘演算法叫「CMP-Miner」，以找尋時間序列資料庫中封閉性多序列樣式。我們的方法可以分為三個階段。第一階段，我們將每個時間序列轉換成一個符號序列。第二階段，我們產生所有的頻繁樣式，並且在產生的過程中對這些樣式做檢查 ...
李梓煜, Lee, Tzu-Yu
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Algorithms for Extracting Frequent Episodes in the Process of Temporal Data Mining [PDF]
An important aspect in the data mining process is the discovery of patterns having a great influence on the studied problem. The purpose of this paper is to study the frequent episodes data mining through the use of parallel pattern discovery algorithms.
Alexandru PIRJAN
core
Mining Top-k Closed Sequential Patterns in Sequential Databases
, 2014 Iosr Journals +1 more
openalex +1 more source