Results 121 to 130 of about 4,031,702 (245)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Mining high utility sequential patterns [PDF]
, 2015 University of Technology Sydney. Faculty of Engineering and Information Technology.Sequential pattern mining refers to the identification of frequent subsequences in sequence databases as patterns.
Yin, J
core
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Maximal sequential patterns mining with timing constraints
, 2010 碩士循序樣式探勘的目的是從資料庫中，尋找頻繁出現且有順序的樣式，通常這些樣式會再被轉換成先前所不知道的、有用的與有價值的資訊。由於資料庫中通常存在大量且長時間的資料，因此循序樣式探勘往往需要花上大量時間。但是一般的頻繁循序樣式探勘演算法無法針對要尋找之頻繁循序樣式的時間條件加以限制，使得探勘得到的頻繁循序樣式太多且不易應用。探勘最長頻繁循序樣式雖可得到意義相同且較精簡的樣式集合，但針對長度為k之最長頻繁循序樣式探勘，不論是以PrefixSpan或是Apriori為基礎的演算法皆必須經過k個回合的探勘 ...
林師晟; Lin, Shi-cheng
core
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
On closed queueing networks with mixed preemptive resume priority servers. [PDF]
This paper discusses a typical closed queueing network model in which multiple preemptive resume servers are present with different priority structures at each priority node. An algorithm is developed that is applicable for the three-node two-class model
Leemans, Herlinde, Dedene, Guido
core
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source