Results 91 to 100 of about 131,470 (252)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Closeness and Residual Closeness of Harary Graphs [PDF]
Analysis of a network in terms of vulnerability is one of the most significant problems. Graph theory serves as a valuable tool for solving complex network problems, and there exist numerous graph-theoretic parameters to analyze the system\u27s stability.
Aytac, Aysun, Golpek, Hande Tuncel
core +2 more sources
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Interviewing mothers: reflections on closeness and reflexivity in research encounters [PDF]
, 2011 Taking as a starting point the idea that a researcher's subjectivity is data and a resource for interpretation, I write about my own experience of combining motherhood and paid work, undertaking a psychosocial study of first time motherhood. I reflect on
Elliott, H, Elliott, Heather
core
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Jurnal Agrisep, 2018 Risk perceptions needs to be developed through risk communication. Without it, farmers' awareness risks is low. The paper is aimed to explain risk communication in Rindu Alam Farmer Group using Social Network Analysis (SNA) Method.
Raesa Harlina +2 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
, 2007 The purpose of this study is to explore the variation in emotional closeness in the adult grandchild and grandparent relationship in relation to the occur-rence of potentially stressful life events in childhood.
Wood, Suzanne, Liossis, Poppy
core +1 more source