Results 111 to 120 of about 71,434 (279)

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Centrality-Based Sombor Index for Network Systems with Applications to Molecular Chemistry and Disease Transmission Networks

Transactions on Fuzzy Sets and Systems
A number is a graphical invariant in graph theory if it is invariant under graph automorphism. In molecular graph theory, graphical invariants are known as topological indices.
Shaikh Ibrahim Abdullah, Maryam Alkandari, Kajal De, Mislav Balkovic   +3 more
doaj  

Research on the spatial correlation structure of urban agglomeration economic growth and its threshold effects in Northeast China

Frontiers in Sustainable Cities
IntroductionThis study investigates the mechanisms through which the internal network structures of urban agglomerations influence economic growth.MethodsBased on panel data from 50 cities in Northeast China, spanning the period 2000 to 2019, a gravity ...
Qiao Li, Yan Zong, Zhen Quan, Jia Li
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Equalizing Closeness Centralities via Edge Additions

Graph modification problems with the goal of optimizing some measure of a given node's network position have a rich history in the algorithms literature. Less commonly explored are modification problems with the goal of equalizing positions, though this class of problems is well-motivated from the perspective of equalizing social capital, i.e ...
Crane, Alex, Friedler, Sorelle A., Patel, Mihir, Sullivan, Blair D.   +3 more
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Closeness centrality reconstruction of tree graphs

Central European Journal of Operations Research
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Viktor Homolya, Tamás Vinkó
openaire   +2 more sources

Hypertension and the Metabolic Syndrome: closely related central origin?

International Congress Series, 2000
In primary hypertension a mild hyperresponsiveness of hypothalamic, sympatho-hormonal centres to psychosocial stimuli forms a major pathogenetic element, although high salt intake in some subjects may contribute via volume expansion. Hypertension is often associated with another "civilisation" disorder, the metabolic syndrome, defined as abdominal ...
P, Björntorp, G, Holm, R, Rosmond, B, Folkow   +3 more
openaire   +2 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source