Results 51 to 60 of about 71,117 (287)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Purpose Chemoimmunotherapy with irinotecan, temozolomide, and dinutuximab (I/T/DIN) has emerged as first‐line therapy for relapsed/refractory (r/r) high‐risk neuroblastoma (HRNB) in North America. Topotecan and cyclophosphamide (T/C) are often used in combination with dinutuximab in the setting of lack of response, progression, or incomplete ...
Benjamin J. Lerman +17 more
wiley +1 more source
Benchmarking Measures of Network Influence [PDF]
, 2016 Identifying key agents for the transmission of diseases (ideas, technology, etc.) across social networks has predominantly relied on measures of centrality on a static base network or a temporally flattened graph of agent interactions.
Bramson, Aaron, Vandermarliere, Benjamin
core +3 more sources
How accurate and statistically robust are catalytic site predictions based on closeness centrality?
BMC Bioinformatics, 2007 Background We examine the accuracy of enzyme catalytic residue predictions from a network representation of protein structure. In this model, amino acid α-carbons specify vertices within a graph and edges connect vertices that are proximal in structure ...
Livesay Dennis R, Chea Eric
doaj +1 more source
Discriminative Distance-Based Network Indices with Application to Link Prediction [PDF]
, 2018 In large networks, using the length of shortest paths as the distance measure has shortcomings. A well-studied shortcoming is that extending it to disconnected graphs and directed graphs is controversial.
Abdessalem, Talel +2 more
core +1 more source
Closeness Centrality Algorithms For Multilayer Networks
, 2022 Centrality measures for simple graphs are well-defined and several main-memory algorithms exist for each. Simple graphs are not adequate for modeling complex data sets with multiple entities and relationships. Multilayer networks (MLNs) have been shown to be better suited, but there are very few algorithms for centrality computation directly on MLNs ...
Pavel, Hamza Reza +2 more
openaire +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background/Objectives Outcomes for pediatric relapsed/refractory (R/R) acute myeloid leukemia (AML) remain dismal. CPX‐351, a liposomal formulation of cytarabine and daunorubicin, may have less off‐target toxicities than traditional chemotherapies and has shown improved outcomes for adults with newly diagnosed therapy‐related AML.
Jonathan D. Bender +17 more
wiley +1 more source
Hallucination of closed repeat proteins containing central pockets
Nature Structural & Molecular Biology, 2022 AbstractIn pseudocyclic proteins such as TIM barrels, β barrels, and some helical transmembrane channels, a single subunit is repeated in a cyclic pattern, giving rise to a central cavity which can serve as a pocket for ligand binding or enzymatic activity.
Linna An +11 more
openaire +3 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Purpose Malignant rhabdoid tumor of the kidney (MRTK) is a rare, aggressive tumor seen in young children. The optimal timing of resection for locally advanced tumors is not well‐defined. The purpose of this study is to evaluate modern oncologic outcomes and the impact of surgical timing. Methods A multicenter retrospective review was performed
Hannah N. Rinehardt +76 more
wiley +1 more source
Journal of King Saud University: Computer and Information Sciences, 2018 We analyze a suite of 48 real-world networks and compute the decay centrality (DEC) of the vertices for the complete range of values for the decay parameter δ ∊ (0, 1) as well as determine the Pearson's correlation coefficient (PCC) between the DECδ ...
Natarajan Meghanathan
doaj +1 more source
Graph Theory Approach to COVID-19 Transmission by Municipalities and Age Groups
Mathematical and Computational Applications, 2022 The COVID-19 pandemic remains a global problem that affects the health of millions of people and the world economy. Identifying how the movement of people between regions of the world, countries, and municipalities and how the close contact between ...
Pedro Machado +4 more
doaj +1 more source