Results 81 to 90 of about 175,302 (247)

Accessibility measurement of highway transportation networks based on closeness-accessibility.

PLoS ONE
Accessibility is a central concept in transport geography research. Quantitative assessment of highway network accessibility aids in assessing road network efficiency, urban layout optimization, functional zoning and sustainable development.
Yuanyuan Zhang, Weidong Song, Jinguang Sun, Peng Dai   +3 more
doaj   +1 more source

A Novel Multi-Indicator Evaluation Algorithm for Identifying the Important Nodes in Complex Networks

Journal of Algorithms & Computational Technology, 2015
Identification of important nodes is an emerging hot topic in complex networks over the last few years. Various measures have been proposed to characterize the importance of nodes in complex networks, such as the degree, betweenness, closeness, etc.
Fang Hu, Yuhua Liu, Jianzhi Jin
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Linking the Network Centrality Measures Closeness and Degree: Additional Data

, 2022
Data and additional information to support article "Linking the Network Centrality Measures Closeness and Degree" by Tim S Evans and Bingsheng Chen.
Tim Evans (98566), Bingsheng Chen (4450744)   +1 more
core   +1 more source

Rank correlation between centrality metrics in complex networks: an empirical study

Open Physics, 2018
Centrality is widely used to measure which nodes are important in a network. In recent decades, numerous metrics have been proposed with varying computation complexity.
Shao Chengcheng, Cui Pengshuai, Xun Peng, Peng Yuxing, Jiang Xinwen   +4 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

The effect of closeness centrality on Node Equilibrium Population.

, 2019
(A) Average resource import and (B) Node Equilibrium Population (NEP) as a function of the closeness centrality of the 100 node network under two out of phase variability scenarios: low amplitude high frequency (LAHF) and high amplitude low frequency ...
Jasper R. F. W. Leuven (6508541), Alexander G. Dolfing (6508538), Brian J. Dermody (344904)   +2 more
core   +1 more source