Results 101 to 110 of about 37,867 (253)

Genomic characterization of nine Clostridioides difficile strains isolated from Korean patients with Clostridioides difficile infection

Gut Pathogens, 2021
Background Clostridioides difficile infection (CDI) is an infectious nosocomial disease caused by Clostridioides difficile, an opportunistic pathogen that occurs in the intestine after extensive antibiotic regimens. Results Nine C.
Seung Woo Ahn, Se Hee Lee, Uh Jin Kim, Hee-Chang Jang, Hak-Jong Choi, Hyon E. Choy, Seung Ji Kang, Seong Woon Roh   +7 more
doaj   +1 more source

Whole microbiota transplantation restores gut homeostasis throughout the gastrointestinal tract

iMeta, Volume 4, Issue 6, December 2025.
This study introduces whole microbiota transplantation (WMT), a synergistic therapeutic approach that concurrently transplants small intestinal and fecal microbiota. In germ‐free mice, WMT outperforms conventional fecal microbiota transplantation (FMT) in restoring gut microbiota diversity and abundance.
Bufu Tang, Yuan Cao, Jiasu Li, Nan Gao, Pingting Gao, Xiaochao Chen, Zunzhen Ming, Zhaoshen Li, Weiliang Hou   +8 more
wiley   +1 more source

The cytotoxic synergy between Clostridioides difficile toxin B and proinflammatory cytokines: an unholy alliance favoring the onset of Clostridioides difficile infection and relapses

MicrobiologyOpen, 2020
Clostridioides difficile infection (CDI) represents an important health problem worldwide, with significant morbidity and mortality. This infection has also high recurrence rates, whose pathophysiological grounds are still poorly understood. Based on our
Gabrio Bassotti, Andrea Marchegiani, Pierfrancesco Marconi, Katia Fettucciari   +3 more
doaj   +1 more source

Extracellular Vesicles in Nonalcoholic Fatty Liver Disease: Mechanisms and Therapeutic Opportunities

iNew Medicine, Volume 1, Issue 1, December 2025.
The role of extracellular vesicles (EVs) in the progression of nonalcoholic fatty liver disease (NAFLD). Donor cells release EVs containing various molecules such as cholesterol, ceramide, sphingomyelin, miRNA, DNA, proteins, and lipids. These EVs are taken up by multiple recipient cells including Kupffer cells, adipocytes, β cells, adipose tissue ...
Yunsheng Dong, Lei Xiong, Nina Zhu, Zihan Wang, Hanqi Xia, Chen Cheng, Jianshang Huang, Yiran Han, Abduxukur Rahman, Junhao Zhao, Chonggui Jiang, Li Zuo, Hua Wang   +12 more
wiley   +1 more source

Decreases in Antimicrobial Use Associated With Multihospital Implementation of Electronic Antimicrobial Stewardship Tools. [PDF]

, 2020
BackgroundAntimicrobial stewards may benefit from comparative data to inform interventions that promote optimal inpatient antimicrobial use.MethodsAntimicrobial stewards from 8 geographically dispersed Veterans Affairs (VA) inpatient facilities ...
Butler, Jorie M, Chou, Ann F, Glassman, Peter A, Goetz, Matthew Bidwell, Graber, Christopher J, Jones, Makoto M, Madaras-Kelly, Karl, Samore, Matthew H, Weir, Charlene, Youn, Sarah Y, Zhang, Yue   +10 more
core   +1 more source

Next‐Generation Sequencing in Infectious‐Disease Diagnostics: Economic, Regulatory, and Clinical Pathways to Adoption

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
Next‐generation sequencing (NGS) is poised to transform infectious‐disease diagnostics. Falling per‐sample costs, new CPT codes and FDA pathways, and 24‐h, multiplexed resistome reports converge to deliver faster, evidence‐based therapy and stronger surveillance. Our roadmap links the economic, regulatory, and clinical pillars to accelerate routine NGS
John Osei Sekyere
wiley   +1 more source

Modeling inpatient and outpatient antibiotic stewardship interventions to reduce the burden of Clostridioides difficile infection in a regional healthcare network [PDF]

, 2020
Antibiotic exposure can lead to unintended outcomes, including drug-drug interactions, adverse drug events, and healthcare-associated infections like Clostridioides difficile infection (CDI). Improving antibiotic use is critical to reduce an individual's
Bobashev, G., CDC MInD-Healthcare Network, DiBiase, L., Endres-Dighe, S., Hilscher, R., Jones, K., Lewis, J., MacFarquhar, J., Marx, A., Munoz, B., Rhea, S., Rineer, J., Sickbert-Bennett, E., Weber, D.J.   +13 more
core   +2 more sources

The Role of Machine Learning in Addressing Antibiotic Resistance: A New Era in Infectious Disease Control

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
Artificial intelligence accelerates the discovery of new antibiotics by rapidly analyzing vast chemical libraries to combat antimicrobial resistance effectively. AI systems predict antibiotic resistance trends, helping researchers design targeted therapies, and prevent the spread of multidrug‐resistant infections. ABSTRACT Antimicrobial resistance (AMR)
Akmal Zubair, Mohd Fazil, Muhammad Jawad, Safa Wdidi   +3 more
wiley   +1 more source

Clostridioides difficile Infection

RGUHS Journal of Medical Sciences, 2022
In the past decade Clostrdioides difficile has become a leading enteric pathogen causing antibiotic-associated diarrohoea and colitis. The manifestations range from diarrhoea to life-threatening damage to the large intestine. It is noted as a nosocomial and community acquired infection in most of the countries including India.
openaire   +1 more source

Comparative Genomics and Virulence Mechanisms to Identify Genes Related to Mucin O‐Glycan Degradation and Pathogenicity in a Potentially Multidrug‐Resistant Clostridium tertium Strain

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
The comparative genomic analysis provides information about how C. tertium HGMC01 strain cause disease through mucin glycan degradation, colonization, multidrug resistance, and modulation of immune responses. Moreover, this analysis data suggest that this strain interacts with host cells by degrading mucin in the gut, potentially through recognition or
Seonghun Kim, Ji Young Kang, Jung‐Sook Lee   +2 more
wiley   +1 more source