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Clostridium difficile infection [PDF]

Nature Reviews Disease Primers, 2016
Infection of the colon with the Gram-positive bacterium Clostridium difficile is potentially life threatening, especially in elderly people and in patients who have dysbiosis of the gut microbiota following antimicrobial drug exposure. C. difficile is the leading cause of health-care-associated infective diarrhoea. The life cycle of C.
Wiep Klaas Smits, Dena Lyras, D Borden Lacy   +2 more
exaly   +11 more sources

Molecular epidemiology and antimicrobial resistance of Clostridioides difficile in Germany, 2014–2019

International Journal of Medical Microbiology, 2021
Clostridioides difficile is a Gram positive spore-forming rod and mainly responsible for nosocomial diarrhea in developed nations. Molecular and antimicrobial surveillance is important for monitoring the strain composition including genotypes of high ...
Ahmed Mohamed Mostafa Abdrabou, Zia Ul Habib Bajwa, Alexander Halfmann, Alexander Mellmann, Anna Nimmesgern, Lena Margardt, Markus Bischoff, Lutz von Müller, Barbara Gärtner, Fabian K. Berger   +9 more
doaj   +1 more source

Assessment of the Effect of Multidrug Resistance Clostridium difficile Clinical Strains on the Dynamics of Clostridium difficile Infection Rate at Pediatric Oncological Hospital

Эпидемиология и вакцинопрофилактика, 2021
Relevance. At the children's oncological hospital guidelines to treat patients with several groups of antibiotics at the same time, which ensures the formation of multi-resistant strains of Clostridium difficile, which have a selective advantage for the ...
M. G. Shvydkaya, A. M. Zatevalov, D. T. Dzhandarova, S. D. Mitrokhin, O. E. Orlova   +4 more
doaj   +1 more source

Molecular epidemiology and antimicrobial resistance of Clostridioides difficile detected in chicken, soil and human samples from Zimbabwe

International Journal of Infectious Diseases, 2020
Background: Clostridioides difficile is the major cause of infectious nosocomial diarrhoea in industrialized nations. Data on the occurrence of C. difficile in Africa, ribotype (RT) distribution, antimicrobial susceptibility patterns and potential ...
Fabian K. Berger, Alexander Mellmann, Markus Bischoff, Lutz von Müller, Sören L. Becker, Clifford Simango, Barbara Gärtner   +6 more
doaj   +1 more source

Риск развития Clostridium difficile инфекции, связанный с применением различных групп антибиотиков и их сочетаний, у детей в онкологическом стационаре

Microbiology Independent Research Journal, 2020
Пациенты детского онкологического стационара находятся в группе риска развития Clostridium difficile инфекции. Цель данного исследования состояла в определении степени риска развития Clostridium difficile инфекции в детском онкологическом стационаре ...
М. Г. Швыдкая, А. М. Затевалов, Д. Т. Джандарова, С. Д. Митрохин   +3 more
doaj   +1 more source

Clostridium difficile инфекции у пациентов детского онкологического стационара: проблемы культивирования анаэробной кишечной флоры и лечения

Microbiology Independent Research Journal, 2021
В последние годы в мире наблюдается рост числа инфекционных заболеваний, вызванных Clostridium difficile со значи-тельным увеличением рецидивов и смертности, в том числе среди онкологических больных – пациентов стационаров.
М. Г. Швыдкая, Д. Т. Джандарова, С. Д. Митрохин   +2 more
doaj   +1 more source

Epidemiology of Clostridioides difficile Infections in Germany, 2010–2019: A Review from Four Public Databases

Infectious Diseases and Therapy, 2023
Introduction Clostridioides difficile infection (CDI) is a recognized global threat especially for vulnerable populations. It is of particular concern to healthcare providers as it is found in both hospital and community settings, with severe courses ...
Gordon Brestrich, Frederick J. Angulo, Fabian K. Berger, Christian Brösamle, Stefan Hagel, Andreas Leischker, Christoph Lübbert, Friederike Maechler, Sophie-Susann Merbecks, Nadia Minarovic, Jennifer C. Moïsi, Lutz von Müller, Phillip A. Reuken, Thomas Weinke, Holly Yu, Alexander Mellmann   +15 more
doaj   +1 more source

Prevalence and pathogenicity of binary toxin–positive Clostridium difficile strains that do not produce toxins A and B

New Microbes and New Infections, 2015
Clostridium difficile causes antibiotic-associated diarrhoea and pseudomembranous colitis. The main virulence factors of C. difficile are the toxins A (TcdA) and B (TcdB). A third toxin, called binary toxin (CDT), can be detected in 17% to 23% of strains,
C. Eckert, A. Emirian, A. Le Monnier, L. Cathala, H. De Montclos, J. Goret, P. Berger, A. Petit, A. De Chevigny, H. Jean-Pierre, B. Nebbad, S. Camiade, R. Meckenstock, V. Lalande, H. Marchandin, F. Barbut   +15 more
doaj   +1 more source

Clostridium difficile infection

Autopsy and Case Reports, 2014
Clostridium difficile infection (CDI) is a significant and increasing medical problem, surpassing methicillin-resistant Staphylococcus aureus as the most common hospital-onset or facility-associated infection, and a key element in the challenging battle against hospital-acquired infections.
Stephen A. Geller, Fernando Peixoto Ferraz de Campos   +1 more
openaire   +5 more sources

The risk of developing a Clostridium difficile infection from the administration of different classes of antibiotics and their combinations to children in an oncological hospital

Microbiology Independent Research Journal, 2020
Patients in pediatric oncological hospitals are at risk of developing a Clostridium difficile infection. The purpose of this study was to determine the risk of developing a Clostridium difficile infection in patients who are treated with antibiotics ...
Mariya G. Shvydkaya, Aleksandr M. Zatevalov, Dzhamilya T. Dzhandarova, Sergey D. Mitrokhin   +3 more
doaj   +1 more source