Results 31 to 40 of about 232,533 (233)

The role of a sequencing-based clinical intestinal screening test in patients at high-risk for Clostridium difficile and other pathogens: a case report

Journal of Medical Case Reports, 2019
Background Hospitalization and antibiotic treatment can put patients at high risk for Clostridium difficile infection, where a disturbance of the gut microbiome allows for Clostridium difficile proliferation and associated symptoms, including mild ...
Maureen Hitschfeld, Elena Tovar, Sarah Gupta, Elisabeth M. Bik, Christina Palmer, Michael C. Hoaglin, Daniel E. Almonacid, Jessica Richman, Zachary S. Apte   +8 more
doaj   +1 more source

Clostridium difficile – still a problem among the XXI century in case of geriatic patient

Journal of Medical Science, 2017
Introduction. The disease caused by Clostridium difficile (CzcD - Clostridium difficile -associated disease) - was defined by the Centres for Disease Control and Prevention in Atlanta in 2007 in order to standardize monitoring conditions of diarrhea ...
Agnieszka Ulatowska, Katarzyna Plagens-Rotman, Małgorzata Piskorz-Szymendera, Elżbieta Włodarczyk, Natalia Smolarek, Izabela Miechowicz, Andrzej Jóźwiak, Grażyna Bączyk   +7 more
doaj   +1 more source

Emergence and global spread of epidemic healthcare-associated clostridium difficile [PDF]

, 2012
Epidemic C. difficile (027/BI/NAP1) has rapidly emerged in the past decade as the leading cause of antibiotic-associated diarrhea worldwide. However, the key events in evolutionary history leading to its emergence and the subsequent patterns of global ...
Hawkey, P.r, Brazier, Jon, Martin, Melissa J, Fairley, Derek, Brown, D., Kim, H.J., Kuijper, Ed, Kato, Haru, Coia, JE, Kathleen B Bamford, Tse Hsien Koh, Kim, HJ, He, M., Wren, B.W., Miyajima, Fabio, Riley, Tom, Brazier, J. S., Kato, H., Harris, Simon R, D'Arc, S., Butt, E., Nick M Brown, Gerding, D, Martin, M.J., Wren, BW, Paul Roberts, Douce, G, Pirmohamed, M, Munir Pirmohamed, Louise Ellison, Songer, Glen, Songer, G, Coia, John E., He, M, Brendan W Wren, Douce, Gill, Kuijper, E., Sharon J Peacock, Pickard, Derek J, Butt, Emma, Mark Wilcox, Lawley, Trevor D, Dale Gerding, Wren, Brendan W, Songer, G., Senoh, Mitsutoshi, Haru Kato, Mitsutoshi Senoh, D'Arc, S, Hee Jung Kim, Pirmohamed, M., Connor, Thomas Richard, Ellison, Louise, Brown, Nick M, Wilcox, Mark, Miyajima, F, Pickard, Derek J., Harris, S.R., Roberts, Paul, Koh, Tse Hsien, Melissa J Martin, Julian Parkhill, Hawkey, P., Louie, T., Bamford, KB, Coia, J., Dougan, Gordon, Coia, John E, Parkhill, Julian, Hawkey, P, Ed Kuijper, Bamford, Kathleen B., Thomas R Connor, Gill Douce, Glen Songer, Pickard, D.J., Simon R Harris, Tom Louie, Derek Fairley, Fairley, D, Miyajima, F., Wilcox, M, Parkhill, J, Michell, S., Tom Riley, Louie, Tom, Harris, Simon R., Louie, T, Lawley, T.D., Bamford, K.B., He, Miao, Gerding, Dale, Connor, T.R., Peacock, Sharon J., Kuijper, E, Butt, E, Peacock, SJ, Brown, Derek, Senoh, M., Gordon Dougan, Pirmohamed, Munir, Gerding, D., Ellison, L, Peter Hawkey, Koh, T.H., Harris, SR, Brazier, J., Wilcox, M., Trevor D Lawley, Coia, J.E., Emma Butt, Ellison, L., Peacock, Sharon J, Brown, NM, Michell, S, Derek Brown, Derek J Pickard, Brown, Nick M., 김희정, Martin, MJ, Peacock, S.J., Brown, N.M., Dougan, G., Brown, D, Riley, T., Kim, Hee Jung, Brazier, J, Kato, H, Connor, Thomas R, Fairley, D., Parkhill, J., Stephanie D'Arc, Wren, Brendan W., D'Arc, Stephanie, Douce, G., Lawley, TD, John E Coia, Fabio Miyajima, Michell, Stephen, Jon Brazier, Lawley, Trevor D., Martin, Melissa J., Miao He, Stephen Michell, Roberts, P., Koh, TH, Hawkey, Peter, Pickard, DJ, Bamford, Kathleen B, Douce, G.l, Roberts, P, Riley, T, Connor, TR, Senoh, M, Dougan, G   +154 more
core   +1 more source

The Recent Emergence of Clostridium difficile Infection in Romanian Hospitals is Associated with a High Prevalence of Polymerase Chain Reaction Ribotype 027

Balkan Medical Journal, 2018
Aims: To investigate the epidemiology of Clostridium difficile infection in Romanian hospitals. Methods: A survey was conducted at nine hospitals throughout Romania between November 2013 and February 2014.
Gabriel Adrian Popescu, Roxana Serban, Adriana Pistol, Andreea Niculcea, Daniela Lemeni, Ioana Sabina Macovei, Daniela Tălăpan, Alexandru Rafila, Dragoş Florea   +8 more
doaj   +1 more source

Disarming Clostridium difficile

Chemistry & Biology, 2010
In this issue, Puriet al. (2010) present inhibitors that prevent the autocatalytic activation of the clostridial toxin TcdB in vivo. Their approach is likely to provide guidance for the development of novel drugs targeting virulence factors and thereby rendering bacterial pathogens innocuous.
Gersch, Malte, Sieber, Stephan A.
openaire   +2 more sources

Emergence of new PCR ribotypes from the hypervirulent Clostridium difficile 027 lineage. [PDF]

, 2011
Clostridium difficile is the most common cause of antibiotic-associated diarrhoea worldwide. Over the past 10 years, the incidence and severity of disease have increased in North America and Europe due to the emergence of a hypervirulent clone designated
Valiente, Esmeralda, Michelle D. Cairns, Brendan W. Wren, Dawson, Lisa F, Stabler, Richard A, Cairns, Michelle D, Wren, Brendan W, Esmeralda Valiente, Richard A. Stabler, Lisa F. Dawson   +9 more
core   +1 more source

The pathogenicity of Clostridium difficile [PDF]

Clinical Microbiology and Infection, 2001
It is now well established that the major virulence factors of C. difficile are the two toxins A and B. However, the organism possesses an array of other putative virulence factors that may be important for localisation within the colon, and in evasion of the immune system. It has been observed that certain types of C. difficile are more commonly found
Poxton, I.R., McCoubrey, J., Blair, G.
openaire   +2 more sources

Investigation into the mobile genetic elements of Clostridium difficile [PDF]

, 2013
Clostridium difficile is a pathogenic bacterium that can colonise both humans and various animals. Toxin production leads to clinical symptoms ranging from mild to severe diarrhoea and can result in potentially fatal pseudomembranous colitis.
Brouwer, MSM
core  

Cost-effectiveness analysis of fidaxomicin versus vancomycin in Clostridium difficile infection [PDF]

, 2014
OBJECTIVES: Fidaxomicin was non-inferior to vancomycin with respect to clinical cure rates in the treatment of Clostridium difficile infections (CDIs) in two Phase III trials, but was associated with significantly fewer recurrences than vancomycin.
Cornely, Oliver A., Odufowora-Sita, Olatunji, Van Engen, Anke K., Odeyemi, Isaac A. O., Retsa, Peny, Nathwani, Dilip   +5 more
core   +1 more source

Genetically Programmed Shape‐Morphing of Engineered Living Materials

Advanced Functional Materials, EarlyView.
Here, bacterial and mammalian engineered living materials (ELMs) are presented, in which living cells direct genetically programmed and enzymatically mediated shape‐morphing. The resulting deformation and shape‐recovery can be actuated in a genetically controlled manner by an ELM incorporating out‐of‐equilibrium counteracting biochemical reactions with
Jan Becker, Yuchen Liu, Miguel Baños, Rosanne Schmachtenberg, Mahmudul Hasan, Claudia Fink‐Straube, Luai R. Khoury, Wilfried Weber   +7 more
wiley   +1 more source