Results 21 to 30 of about 47,365 (201)

Risk factors for infection in HIV-infected patients

SAGE Open Medicine, 2016
Background: Clostridium difficile infection is a healthcare-associated infection resulting in significant morbidity. Although immunosuppression is associated with Clostridium difficile infection acquisition and adverse outcomes, the epidemiology of ...
Hannah Imlay, Daniel Kaul, Krishna Rao
doaj   +1 more source

The role of a sequencing-based clinical intestinal screening test in patients at high-risk for Clostridium difficile and other pathogens: a case report

Journal of Medical Case Reports, 2019
Background Hospitalization and antibiotic treatment can put patients at high risk for Clostridium difficile infection, where a disturbance of the gut microbiome allows for Clostridium difficile proliferation and associated symptoms, including mild ...
Maureen Hitschfeld, Elena Tovar, Sarah Gupta, Elisabeth M. Bik, Christina Palmer, Michael C. Hoaglin, Daniel E. Almonacid, Jessica Richman, Zachary S. Apte   +8 more
doaj   +1 more source

Clostridium difficile – still a problem among the XXI century in case of geriatic patient

Journal of Medical Science, 2017
Introduction. The disease caused by Clostridium difficile (CzcD - Clostridium difficile -associated disease) - was defined by the Centres for Disease Control and Prevention in Atlanta in 2007 in order to standardize monitoring conditions of diarrhea ...
Agnieszka Ulatowska, Katarzyna Plagens-Rotman, Małgorzata Piskorz-Szymendera, Elżbieta Włodarczyk, Natalia Smolarek, Izabela Miechowicz, Andrzej Jóźwiak, Grażyna Bączyk   +7 more
doaj   +1 more source

Clostridium difficile and the microbiota [PDF]

Journal of Clinical Investigation, 2014
Clostridium difficile infection (CDI) is the leading health care-associated illness. Both human and animal models have demonstrated the importance of the gut microbiota's capability of providing colonization resistance against C. difficile. Risk factors for disease development include antibiotic use, which disrupts the gut microbiota, leading to the ...
Anna M, Seekatz, Vincent B, Young
openaire   +2 more sources

The Recent Emergence of Clostridium difficile Infection in Romanian Hospitals is Associated with a High Prevalence of Polymerase Chain Reaction Ribotype 027

Balkan Medical Journal, 2018
Aims: To investigate the epidemiology of Clostridium difficile infection in Romanian hospitals. Methods: A survey was conducted at nine hospitals throughout Romania between November 2013 and February 2014.
Gabriel Adrian Popescu, Roxana Serban, Adriana Pistol, Andreea Niculcea, Daniela Lemeni, Ioana Sabina Macovei, Daniela Tălăpan, Alexandru Rafila, Dragoş Florea   +8 more
doaj   +1 more source

Typing of Clostridium difficile [PDF]

Clinical Microbiology and Infection, 2001
Clostridium difficile is primarily recognised as a nosocomially acquired pathogen manifesting in gastrointestinal disease subsequent to the patient receiving broad-spectrum antibiotics. Infection can be sporadic, but outbreaks commonly occur within a ward or hospital as a result of cross-infection. Since the 1980s, the epidemiology of C.
openaire   +2 more sources

Clostridium difficile infection [PDF]

The Lancet, 2008
Clostridium difficile is a Gram-positive, anaerobic, spore-producing anaerobe [1] responsible for approximately 50–70% of gastrointestinal infections in hospitalized patients [2, 3]. An episode of C. difficile infection (CDI) is defined as a clinical picture compatible with CDI (i.
Kuipers, Ernst, Surawicz, CM
openaire   +5 more sources

Modern Recent on the Laboratory Diagnosis of Clostridium Difficile-associated Infection

Журнал инфектологии, 2014
In the review the current information on the laboratory diagnosis of Clostridium difficile-associated infection. Made a critical assessment of the effectiveness and specificity of the modern methods of diagnosis: methods of isolation and identification ...
A. S. Kvet naya,, P. S. Makridi, M. K. Behtereva   +2 more
doaj   +1 more source

Ciclopirox Olamine Inhibits the NLRP3 Inflammasome to Alleviate Inflammatory Diseases

Advanced Science, EarlyView.
There is no drug targeting the NLRP3 inflammasome that has been approved for use in clinical settings. Ciclopirox olamine (CPX), an antifungal agent approved by the US Food and Drug Administration (FDA), is identified as a specific and potent NLRP3 inflammasome inhibitor. CPX targets the NACHT domain of NLRP3 at Y381 to impair NLRP3 oligomerization and
Xinyu Xia, Hui You, Ke Zhang, Hui Jiang, Hongping Liu, Lianghua Liu, Aijie Zhang, You Zhou   +7 more
wiley   +1 more source

Disarming Clostridium difficile

Chemistry & Biology, 2010
In this issue, Puriet al. (2010) present inhibitors that prevent the autocatalytic activation of the clostridial toxin TcdB in vivo. Their approach is likely to provide guidance for the development of novel drugs targeting virulence factors and thereby rendering bacterial pathogens innocuous.
Gersch, Malte, Sieber, Stephan A.
openaire   +2 more sources