Results 101 to 110 of about 113,640 (277)

Cost-Effectiveness Analysis of Bezlotoxumab Added to Standard of Care Versus Standard of Care Alone for the Prevention of Recurrent Clostridium difficile Infection in High-Risk Patients in Spain [PDF]

, 2018
Introduction Clostridium difficile infection (CDI) is the major cause of infectious nosocomial diarrhoea and is associated with considerable morbidity, mortality and economic impact.
Aceituno, Susana, Aragón, Belén, Cobo, Javier, Grau, Santiago, Jiang, Yiling, Maratia, Stefano, Pascual, Álvaro, Salavert, Miguel   +7 more
core   +3 more sources

L‐Tryptophan Produced by Bifidobacterium pseudocatenulatum NCU‐08 Delays Aging in SAMP8 Mice by Activating the Sirt1/P53/P21/Rb Signaling Pathway

Aging Cell, EarlyView.
Bifidobacterium pseudocatenulatum NCU‐08, isolated from the feces of centenarians, facilitated the entry of L‐tryptophan into hippocampal neurons of SAMP8 mice, where it was metabolized into NAD+. The increased NAD+ levels activated Sirt1 protein, thereby suppressing the expression of senescence‐associated proteins P53, P21, and Rb, ultimately delaying
Tangchang Xu, Xiaoyun Wu, Yifei Zhang, Yujie Cai, Xinfeng Zhang, Qingwei Zeng, Jie Luo, Jing Wei, Tingtao Chen   +8 more
wiley   +1 more source

Integrated Efficacy and Safety Analysis of Abrocitinib in Adolescents With Moderate‐to‐Severe Atopic Dermatitis

Allergy, EarlyView.
Data were included from adolescents with moderate‐to‐severe AD treated with the JAK1 inhibitor abrocitinib (200 mg/100 mg) across JADE clinical trials. Improvements in skin clearance (per EASI‐75) and itch (per PP‐NRS4) were maintained for up to 112 weeks with both abrocitinib doses.
Amy S. Paller, Lawrence F. Eichenfield, Alan D. Irvine, Carsten Flohr, Andreas Wollenberg, Sébastien Barbarot, Christine Bangert, Jonathan M. Spergel, Andrew Selfridge, Pinaki Biswas, Haiyun Fan, Justine Alderfer, Melissa Watkins, Herwig Koppensteiner   +13 more
wiley   +1 more source

Direct Single‐Dose Drug‐Provocation Test Is Safe for Delabelling Penicillin Low‐Risk Reactions in Adults

Allergy, EarlyView.
We show that direct single‐dose provocation test was both safe and effective in delabeling penicillin allergy in low‐risk adult patients, including those with mild delayed skin reactions and those with unknown reactions, such as childhood labels and past syncope episodes. In those who react in the drug provocation test, a T‐cell mechanism was confirmed
Marina Labella, Julia Rodriguez de Guzmán, Patricia Diez‐Echave, María Salas, Rubén Fernández‐Santamaría, Cristobalina Mayorga, Inmaculada Doña, María José Torres   +7 more
wiley   +1 more source

A retrospective clinical study on the influencing factors of Clostridium difficile infection in elderly patients

Guoji laonian yixue zazhi
[Objective] To investigate the risk factors of Clostridium difficile infection in elderly inpatients and provide the theoretical basis for the prevention and treatment of Clostridium difficile infection.
Yang Chen, Yingjun Gong, Cui Li, Huan Li, Jia Chen, Hui Su, Xiaoming Wang, Xiaoxuan Ning   +7 more
doaj   +1 more source

Pharmacokinetics of surotomycin from phase 1 single and multiple ascending dose studies in healthy volunteers

BMC Pharmacology and Toxicology, 2017
Background Surotomycin, a novel, orally administered, cyclic, lipopeptide antibacterial in development for the treatment of Clostridium difficile-associated diarrhea, has demonstrated minimal intestinal absorption in animal models.
Gurudatt Chandorkar, Qiao Zhan, Julie Donovan, Shruta Rege, Hernando Patino   +4 more
doaj   +1 more source

Presence and molecular characterization of Clostridium difficile and Clostridium perfringens in intestinal compartments of healthy horses [PDF]

, 2012
BACKGROUND: Clostridium difficile and Clostridium perfringens are commonly associated with colitis in equids, but healthy carriers exist. Scarce information is available on the prevalence of Clostridium spp.
Angelika Schoster, Henry Staempfli, Jeffrey Weese, Luis Arroyo, Patricia Shewen   +4 more
core   +2 more sources

Guselkumab in East Asians With Moderate‐to‐Severe Ulcerative Colitis: Subgroup Analysis of the QUASAR Induction and Maintenance Studies

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Background and Aim The global QUASAR (NCT04033445) clinical program demonstrated the efficacy and safety of guselkumab, a dual‐acting interleukin‐23 p19 subunit inhibitor, as induction and maintenance therapy in participants with moderate to severely active ulcerative colitis (UC).
Baili Chen, Byong Duk Ye, Qian Cao, Fumihito Hirai, Masayuki Saruta, Minhu Chen, Susan Pelak, Nicole Shipitofsky, Ye Miao, Keira Herr, Bryan Wahking, Jianmin Zhuo, Tadakazu Hisamatsu   +12 more
wiley   +1 more source

Prevalencia y factores relacionados con la infección por Clostridium difficile en un centro hospitalario de alta complejidad en Cali (Colombia)

Infectio
Resumen Objetivos: Estimar la prevalencia y los factores relacionados con la infección por Clostridium difficile en un hospital de alta complejidad en Cali (Colombia). Métodos: Se realizó un estudio de casos y controles en pacientes que consultaron por
José Millán Oñate-Gutiérrez, María Virginia Villegas, Adriana Correa   +2 more
doaj   +1 more source

The Issue of Early Diagnosis of Intestinal Complications at Antibiotic Therapy in Children

Zdorovʹe Rebenka, 2015
The objective of the research was to improve the timely diagnosis of intestinal complications of antibiotic therapy, caused by Clostridium difficile infection in children.
O.A. Radutna, O.H. Ivanko, N.V. Kyzyma, O.S. Krut   +3 more
doaj   +1 more source