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Clostridium difficile

Nursing Standard, 2007
George, a 55-year-old retired businessman with a diagnosis of myelofibrosis, underwent an allogeneic stem cell transplantation from his human leukocyte antigen-matched brother in June 2006. He was admitted to the hospital for a possible flare of graft-versus-host disease (GVHD) of the gut.
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Clostridium difficile infection

Medicina Clínica (English Edition), 2017
Clostridium difficile infection (CDI) is the main cause of nosocomial diarrhea in industrialized countries and the source of a growing number of cases of diarrhea in the community. The outbreak of the hypervirulent strain belonging to ribotype 027 has increased the incidence and severity of CDI in some countries.
Luis, Alcalá Hernández   +2 more
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Clostridium difficile

Current Opinion in Internal Medicine, 2002
Clostridium difficile is the most commonly identified infective cause of antibiotic associated diarrhoea. Broad spectrum antibiotics, are most frequently incriminated, although short (
Bethan, Stoddart, Mark H, Wilcox
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Community Clostridium difficile

BMJ, 2009
We reviewed clinical and microbiology data on patients with positive results for C difficile toxin in this NHS trust from May 2007 to April 2008.1 General practitioners’ practice in requesting tests for C difficile toxin varied widely. …
Jayakeerthi, Rangaiah   +2 more
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Clostridium difficile Colitis

New England Journal of Medicine, 1994
Clostridium difficile has become one of the commonest pathogens of the lower intestinal tract. This organism appears unique in that infection almost always occurs during or after antibiotic therapy, suggesting that some component of the normal microflora prevents colonization by C. difficile. Once it has overgrown in the colon, C.
C P, Kelly, C, Pothoulakis, J T, LaMont
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Clostridium difficile: An update

Comprehensive Therapy, 2004
Clostridium difficile causes a spectrum of diarrheal illness with the potential for major medical consequences. Although most cases respond quickly to treatment, C. difficile colitis may be severe and life threatening. Recurrent disease represents a particularly challenging problem.
Jonathan, Gonenne, Darrell S, Pardi
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Clostridium difficile Adhesins

2016
Clostridium difficile is responsible for a large spectrum of intestinal diseases ranging from mild diarrhea to fatal colitis depending on the one hand on the strain virulence and on the other on the host. The pathogenesis of C. difficile infection could be seen as a three-step process that takes place after disruption of the digestive microbiota by ...
Séverine, Péchiné   +2 more
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Clostridium difficile Biofilm

2018
Clostridium difficile infection (CDI) is an important healthcare-associated disease worldwide, mainly occurring after antimicrobial therapy. Antibiotics administered to treat a number of infections can promote C. difficile colonization of the gastrointestinal tract and, thus, CDI.
Claudia, Vuotto   +3 more
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Clostridium difficile Toxinotyping

2010
Clostridium difficile shows considerable variability in the PaLoc region encoding two main virulence factors, toxins TcdA and TcdB. Strains with changes in PaLoc are defined as variant toxinotypes and currently 27 such groups are recognized (I to XXVII).
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Clostridium difficile Colitis

Surgical Clinics of North America, 2009
Clostridium difficile is the most common cause of infectious diarrhea in hospitalized patients. Its effects are mediated by C difficile toxins A and B. Recent outbreaks of severe colitis have been associated with a new strain of the bacterium that produces large amounts of the toxins. Although oral metronidazole and oral vancomycin can be used to treat
Philip A, Efron, John E, Mazuski
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