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Clostridium difficile

Gastroenterology Clinics of North America, 2001
Clostridium difficile is a major cause of antibiotic-associated diarrhea and colitis. The incidence of infection with this organism is increasing in hospitals worldwide, consequent to the widespread use of broad-spectrum antibiotics. Pathogenic strains of C. difficile produce two protein exotoxins, toxin A and toxin B, that cause colonic mucosal injury
L, Kyne, R J, Farrell, C P, Kelly
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Clostridium difficile

Current Opinion in Internal Medicine, 2002
Clostridium difficile is the most commonly identified infective cause of antibiotic associated diarrhoea. Broad spectrum antibiotics, are most frequently incriminated, although short (
Bethan, Stoddart, Mark H, Wilcox
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Clostridium Difficile

Clinical Journal of Oncology Nursing, 2007
George, a 55-year-old retired businessman with a diagnosis of myelofibrosis, underwent an allogeneic stem cell transplantation from his human leukocyte antigen-matched brother in June 2006. He was admitted to the hospital for a possible flare of graft-versus-host disease (GVHD) of the gut.
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Clostridium difficile

Current Opinion in Infectious Diseases, 2013
Biological therapies for Clostridium difficile infection (CDI) include probiotics and faecal microbiota transplant (FMT). There is significant interest in their use in treating refractory/recurrent CDI. This review summarizes the latest evidence for these approaches.The small number of randomized controlled trials (RCTs) using probiotics in CDI have ...
Jessica, Martin   +2 more
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Clostridium difficile: An update

Comprehensive Therapy, 2004
Clostridium difficile causes a spectrum of diarrheal illness with the potential for major medical consequences. Although most cases respond quickly to treatment, C. difficile colitis may be severe and life threatening. Recurrent disease represents a particularly challenging problem.
Jonathan, Gonenne, Darrell S, Pardi
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Clostridium difficile Infection

Infectious Disease Clinics of North America, 2017
Clostridium difficile infection is a major health care challenge in terms of patient and economic consequences. For the patient, it is a morbid and sometimes a life-threatening iatrogenic complication of antibiotic treatment. In the United States, the provider's institution may face financial penalties, because the Centers for Disease Control and ...
Luis, Alcalá Hernández   +2 more
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Clostridium difficile Colitis

New England Journal of Medicine, 1994
Clostridium difficile has become one of the commonest pathogens of the lower intestinal tract. This organism appears unique in that infection almost always occurs during or after antibiotic therapy, suggesting that some component of the normal microflora prevents colonization by C. difficile. Once it has overgrown in the colon, C.
C P, Kelly, C, Pothoulakis, J T, LaMont
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Clostridium difficile Adhesins

2016
Clostridium difficile is responsible for a large spectrum of intestinal diseases ranging from mild diarrhea to fatal colitis depending on the one hand on the strain virulence and on the other on the host. The pathogenesis of C. difficile infection could be seen as a three-step process that takes place after disruption of the digestive microbiota by ...
Séverine, Péchiné   +2 more
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Community Clostridium difficile

BMJ, 2009
We reviewed clinical and microbiology data on patients with positive results for C difficile toxin in this NHS trust from May 2007 to April 2008.1 General practitioners’ practice in requesting tests for C difficile toxin varied widely. …
Jayakeerthi, Rangaiah   +2 more
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Clostridium difficile Biofilm

2018
Clostridium difficile infection (CDI) is an important healthcare-associated disease worldwide, mainly occurring after antimicrobial therapy. Antibiotics administered to treat a number of infections can promote C. difficile colonization of the gastrointestinal tract and, thus, CDI.
Claudia, Vuotto   +3 more
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