Results 81 to 90 of about 64,708 (238)

The Issue of Early Diagnosis of Intestinal Complications at Antibiotic Therapy in Children

open access: yesZdorovʹe Rebenka, 2015
The objective of the research was to improve the timely diagnosis of intestinal complications of antibiotic therapy, caused by Clostridium difficile infection in children.
O.A. Radutna   +3 more
doaj   +1 more source

Identification of amino acids essential for angulin‐1/3 binding of the tricellular tight junction binder, angubindin‐1

open access: yesFEBS Open Bio, Volume 16, Issue 1, Page 116-126, January 2026.
Angubindin‐1 binds angulin‐1/‐3 at tricellular tight junctions, enhancing intestinal macromolecule permeation. Alanine scanning identified six essential residues (L562, L598, E638, V640, Y643, and K644) of angubindin‐1 critical for binding to angulin‐1/‐3 and permeation‐enhancing activity, providing insights for the development of targeted noninvasive ...
Taiki Kuzu   +8 more
wiley   +1 more source

Harnessing Next‐Generation 3D Cancer Models to Elucidate Tumor‐Microbiome Crosstalk

open access: yesAdvanced Healthcare Materials, Volume 15, Issue 1, 9 January 2026.
Centralizes the microbiome within 3D tumor‐microbiome model platforms, including spheroids, organoids, 3D‐bioprinted constructs, and microfluidic chips, each enabling structured host‐tumor‐microbe studies. These systems support bacterial colonization, facilitating investigation of microbial impacts on tumor growth, immunity, and therapy. The microbiome
Marina Green Buzhor   +12 more
wiley   +1 more source

Pharmacokinetics of surotomycin from phase 1 single and multiple ascending dose studies in healthy volunteers

open access: yesBMC Pharmacology and Toxicology, 2017
Background Surotomycin, a novel, orally administered, cyclic, lipopeptide antibacterial in development for the treatment of Clostridium difficile-associated diarrhea, has demonstrated minimal intestinal absorption in animal models.
Gurudatt Chandorkar   +4 more
doaj   +1 more source

Aptamer Engineering: Strategies for Discovering Functional Nucleic Acids for Next‐Generation Diagnostics and Biosensing

open access: yesAdvanced Science, Volume 13, Issue 2, 9 January 2026.
The advent of aptamers has highlighted their potential as alternatives to antibodies, overcoming limitations of structural instability and production cost. However, conventional approaches such as SELEX remain slow and labor‐intensive. This review examines recent advances in aptamer engineering, emphasizing in vitro and AI‐driven in silico strategies ...
John V. L. Nguyen   +5 more
wiley   +1 more source

The Effect of Probiotic Yogurt on the Frequency of Clostridium difficile in Old Hospitalized Patients

open access: yesMajallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2019
Background and Aim Clostridium difficile is the main cause of Antibiotic-Associated Diarrhea (AAD) in the hospital setting. Today, the use of probiotics for the prevention and treatment of AAD and colitis is increasing. In this study, we investigated the
Masoomeh Sofian   +4 more
doaj  

Impact of Low Preoperative Prognostic Immune Nutritional Index on Survival and Postoperative Infectious Complications in Patients With Colorectal Cancer

open access: yesAnnals of Gastroenterological Surgery, Volume 10, Issue 1, Page 154-166, January 2026.
This study investigated the prognostic value of the preoperative prognostic immune nutritional index (PINI) in colorectal cancer. A low preoperative PINI was significantly associated with both poor oncological outcomes and an increased risk of postoperative infectious complications.
Shinji Yamashita   +9 more
wiley   +1 more source

Clostridium difficile Infection

open access: yesClinical and Translational Gastroenterology, 2015
Clostridium difficile infection (CDI) affects a broad population and has become so widespread the Centers for Disease Control and Prevention rated C. difficile as an urgent threat in 2013.1, 2 Recent basic-science research has focused on understanding the pathogenesis of the disease and alterations in the microbiome causing susceptibility.
openaire   +2 more sources

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