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Therapeutics involved in managing initial and recurrent Clostridium difficile infection: An updated literature review.

World J Gastrointest Pharmacol Ther
Nagesh VK, Tran HH, Elias D, Kianifar Aguilar I, Sethi T, Menon A, Mansour C, Furman F, Tsotsos K, Subar T, Auda A, Sidiqui A, Lamar J, Wadhwani N, Dey S, Lo A, Atoot A, Weissman S, Sifuentes H, Bangolo AI.   +19 more
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Clostridium difficile Infection

Infectious Disease Clinics of North America, 2017
Clostridium difficile infection is a major health care challenge in terms of patient and economic consequences. For the patient, it is a morbid and sometimes a life-threatening iatrogenic complication of antibiotic treatment. In the United States, the provider's institution may face financial penalties, because the Centers for Disease Control and ...
Luis, Alcalá Hernández, Elena, Reigadas Ramírez, Emilio, Bouza Santiago   +2 more
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Clostridium difficile Infection

Critical Reviews in Clinical Laboratory Sciences, 1996
The spore-forming anaerobe Clostridium difficile has become a serious enteropathogen. Changes in the composition of natural intestinal flora, mainly due to antibiotic therapy, permit its colonization of, and multiplication in, the colon. The disease is caused by (entero)toxin A and (cyto)toxin B, and infection ranges from asymptomatic carrier state and
Dieter H. M. Gröschel, B. Toye
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Clostridium difficileInfection

New England Journal of Medicine, 2015
This article reviews the pathogenesis, epidemiology, diagnosis, and treatment of this nosocomial and potentially fatal infectious diarrhea, as well as the associated risk factors. New treatments include fecal microbiota transplantation for disease that is resistant to vancomycin.
Sam K, Sharma, Kentaro, Nakajima, Parul J, Shukla   +2 more
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Clostridium difficile Infection in the Elderly

Clinics in Geriatric Medicine, 2014
Clostridium difficile-associated illness is an increasingly prevalent and morbid condition. The elderly population is at a disproportionate risk of developing symptomatic disease and associated complications, including progression to severe or fulminant disease, and development of recurrent infections. This article analyzes the factors that influence C
Jonathan M, Keller, Christina M, Surawicz   +1 more
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Update on Clostridium difficile infections

Médecine et Maladies Infectieuses, 2014
Clostridium difficile infections (CDI) occur primarily in hospitalized patients with risk factors such as concomitant or recent use of antibiotics. CDI related additional costs are important for the global population and health-care facilities. CDI epidemiology has changed since 2003: they became more frequent boosted by large outbreaks, more severe ...
Le Monnier, A., Zahar, J.-R., Barbut, F.
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Update on Clostridium difficile infection

Current Opinion in Gastroenterology, 2011
This review summarizes the most recent epidemiological data and advances in research into the pathogenesis, diagnosis and treatment of Clostridium difficile infection (CDI).The epidemiology of CDI has changed with the emergence of hypervirulent strains.
Caoilfhionn, O'Donoghue, Lorraine, Kyne
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Clostridium difficile infection in Thailand

International Journal of Antimicrobial Agents, 2015
Clostridium difficile is the aetiological agent in ca. 20% of cases of antimicrobial-associated diarrhoea in hospitalised adults. Diseases caused by this organism range from mild diarrhoea to occasional fatal pseudomembranous colitis. The epidemiology of C.
Papanin Putsathit, Pattarachai Kiratisin, Puriya Ngamwongsatit, Thomas V. Riley   +3 more
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Infection control: Clostridium Difficile

Nursing and Residential Care, 2007
Clostridium difficile is a gram-positive, spore-forming bacteria that produces toxins when infection occurs. Infection can cause diarrhoea or life-threatening colitis ( Barbut et al, 2007 ). There has been an 85% reduction in hospital-acquired Clostridium difficile infections over the past eight years ( Public Health England, 2014 ).
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Clostridium difficile infection

BMJ, 2009
Rangaiah and colleagues comment that currently used tests for Clostridium difficile toxin are not very sensitive.1 However, the specificity of these commercial assays also ranges from 97% to 99%, meaning that approximately 1-2 out of every 10 positive results using these kits are incorrect.2 False positive results are even more likely when testing ...
Mark H, Wilcox, Tim, Planche
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