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Milestones in Clostridium perfringens research since 1995. [PDF]
AnaerobeMcClane BA, Li J, Uzal FA, Rood JI.
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Clostridium perfringens enterotoxin
Microbial Pathogenesis, 1988Current knowledge of CPE action is briefly summarized in Figure 1. After specific binding to a protein receptor(s), the entire CPE molecule rapidly inserts into membranes forming a complex of 150,000 Mr. Almost simultaneously with insertion, there is a sudden change in ion fluxes.
B A, McClane, P C, Hanna, A P, Wnek
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Clostridium perfringens enterotoxin: a brief review
Biochemical Society Transactions, 1984Ussing chambers were mounted with stripped rabbit ileal mucosa and either crude or pure toxin A added to the mucosal side of the chamber to final concentrations of 800 and 30pg/ml respectively; increases in short-circuit currents of the order of 25pA were observed in both preparations over a period of 90min, at which point the tissue was reponsive to ...
B A, Bartholomew, M F, Stringer
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An overview of Clostridium perfringens enterotoxin
Toxicon, 1996Clostridium perfringens enterotoxin (CPE) is considered to be the virulence factor responsible for causing the symptoms of C. perfringens type A food poisoning and may also be involved in other human and veterinary illnesses. CPE has a unique four-step membrane action that apparently involves: (1) CPE binding to a 50,000 mol.
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Interactions Between Clostridium perfringens Enterotoxin and Claudins
2011Clostridium perfringens enterotoxin (CPE), a single polypeptide of approximately 35 kDa in size, is -associated with type A food poisoning and such non-foodborne gastrointestinal diseases as antibiotic-associated diarrhea and sporadic diarrhea. CPE action begins with binding of the toxin to a claudin -receptor, forming a ∼90 kDa small complex that then
Susan L, Robertson, Bruce A, McClane
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Clostridium Perfringens Enterotoxin-Associated Diarrhoea
1987Enterotoxigenic strains of C. perfringens are now implicated in cases of diarrhoea other than food poisoning. There is good evidence that cross-infection may occur and that cross-infection control measures are helpful in limiting spread of the disease.
S. P. Borriello +3 more
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An investigation into Clostridium perfringens enterotoxin-associated diarrhoea
Journal of Hospital Infection, 1991An investigation was carried out to establish the incidence of diarrhoea associated with the presence of enterotoxigenic Clostridium perfringens. The results indicate a high risk group, namely elderly hospitalized patients, who should be investigated for this organism in a similar way to Clostridium difficile if symptoms occur.
S C, Samuel, P, Hancock, D A, Leigh
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Mechanism of Action of Clostridium perfringens Enterotoxin
1996An enterotoxin produced by Clostridium perfringens during sporulation is a simple protein with a molecular weight of about 35,000 and is a causative agent for the food poisoning by the organism (Todd, 1987). Production of the enterotoxin by the organism and the methods for purification were studied intensively in 1960s and 1970s (Duncan and Strong ...
N, Sugimoto, Y, Horiguchi, M, Matsuda
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Human Disease Associated with Clostridium perfringens Enterotoxin
1997Clostridium perfringens continues to be a common cause of food-borne disease. Characteristics of this organism that contribute to its ability to cause food-borne illness include the formation of heat-resistant spores that survive normal cooking/heating temperatures, a rapid growth rate in warm food, and the production of enterotoxin (CPE) in the human ...
R R, Meer, J G, Songer, D L, Park
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Trypsinization of derivatives of Clostridium perfringens enterotoxin
Letters in Applied Microbiology, 1986Three proteins, named P1, P2 and P3, were separated from purified Clostridium perfringens enterotoxin by high performance liquid chromatography (HPLC) on a DEAE-5PW column. The relative biological activities of P1, P2 and P3 on protein basis determined by the African green monkey kidney (Vero) cell staining assay were 3·0, 1·9 and 1·0, respectively. P1,
T. UEMURA +3 more
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