Results 101 to 110 of about 9,971,653 (340)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Transcatheter closure of Ventricular Septal defects in Malta : initial experience [PDF]

, 2005
Ventricular septal defects (VSD) consist of deficiencies of the wall separating the two ventricles. VSDs are the commonest congenital cardiac defects. Small VSDs rarely require intervention, however, larger defects cause ventricular volume overload with ...
Aquilina, Oscar, DeGiovanni, Joseph V., Manche, Alexander, Magic, Jadran, Grech, Victor E., Formosa Gouder, Mireille, Fenech, Albert   +6 more
core  

Skeletal Anchorage-Assisted Space Closure in a Patient with Bilateral Peg-Shaped Maxillary Lateral Incisors and Severe Crowding

Oral
Background: Peg-shaped maxillary lateral incisors are among the most common developmental anomalies affecting the anterior dentition and are frequently associated with Bolton tooth-size discrepancies and severe crowding.
Antonio Manni, Andrea Boggio, Emma Gotti
doaj   +1 more source

A Novel Temporary Anchorage Device Aided Sectional Mechanics for Simultaneous Orthodontic Retraction and Intrusion

Case Reports in Dentistry, 2020
Closing spaces on light wires with inadequate knowledge and inappropriate mechanics can cause a “roller coaster” effect leading to an improper occlusion.
Adith Venugopal, Paolo Manzano, Sri Rengalakshmi   +2 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Comparison of Skeletal, Dental, and Soft Tissue Changes Before and After Orthodontic Treatment in Patients with Congenitally Missing Bilateral Maxillary Lateral Incisors

Medicina
(1) Background and Objectives: Congenitally missing bilateral maxillary lateral incisors (CMBMLIs) present significant aesthetic, functional, and psychosocial challenges that require an orthodontic approach based on multidisciplinary consensus.
Tuğba Şenel, Orhan Cicek
doaj   +1 more source

The Loss of First Permanent Molar in Young Patients

Česká Stomatologie a Praktické Zubní Lékařství, 2013
Introduction: The loss of first permanent molar significantly reduces the biological quality of the dentition. In addition to prosthetic rehabilitation in indicated cases, we can also take advantage of orthodontic space closure with mesial shift of the ...
M. Koťová, J. Hovorka
doaj   +1 more source

Does the bracket–ligature combination affect the amount of orthodontic space closure over three months? A randomized controlled trial

Journal of orthodontics, 2013
Objective To investigate the effect of bracket–ligature combination on the amount of orthodontic space closure over three months. Design Randomized clinical trial with three parallel groups.
Henry Wong, Jill Collins, D. Tinsley, J. Sandler, P. Benson   +4 more
semanticscholar   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source