Results 121 to 130 of about 816,465 (293)

Nanoscale Buried Interface Control in Silicone Hydrogels Enables a Biointerface Engineering Platform

open access: yesAdvanced Science, EarlyView.
A hydrophilic coating with controllable nanoscale thickness is applied to commercial silicone hydrogel contact lenses. By combining comprehensive multi‐modal three‐dimensional characterization with an advanced algorithm, the thickness and chemical information of these multilayered structures are resolved.
Po‐Hsiang Chen   +5 more
wiley   +1 more source

Collaborative Edge AI Inference Over Cloud-RAN

open access: yesIEEE Transactions on Communications
In this paper, a cloud radio access network (Cloud-RAN) based collaborative edge AI inference architecture is proposed. Specifically, geographically distributed devices capture real-time noise-corrupted sensory data samples and extract the noisy local feature vectors, which are then aggregated at each remote radio head (RRH) to suppress sensing noise ...
Pengfei Zhang   +5 more
openaire   +3 more sources

Mechanism‐Informed Language Modeling and Oxygenated 3D Screening Identify Berberine–Enzalutamide Synergy in Prostate Cancer Models

open access: yesAdvanced Science, EarlyView.
By integrating knowledge‐augmented artificial intelligence with an oxygen‐supplemented 3D screening platform, a synergistic interaction between berberine and enzalutamide is identified. The framework integrates compound mechanisms of action with disease‐relevant signaling context to prioritize candidate combinations and generate testable pathway‐based ...
Chih‐Hui Lo   +15 more
wiley   +1 more source

PDHA1 Hyperactivation‐Mediated Glucose Metabolism Reprogramming Fuels Neutrophil NETosis and Promotes Acute Lung Injury

open access: yesAdvanced Science, EarlyView.
During NETosis, neutrophils shift metabolically toward enhanced OXPHOS and partially reduced glycolysis. This shift is driven by PDHA1 hyperactivity‐dependent selective metabolic reprogramming. The neutrophil‐targeted nanoparticle 3‑FP‑BSA NPs effectively inhibit NETosis and attenuate ALI.
Yu‐Biao Liu   +14 more
wiley   +1 more source

Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes

open access: yesAdvanced Science, EarlyView.
Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao   +7 more
wiley   +1 more source

An AI‐Driven Framework for Directed Self‐Assembly Toward Design‐Technology Co‐Optimization

open access: yesAdvanced Science, EarlyView.
An artificial intelligence (AI)‐driven closed‐loop framework integrates experiment, three‐dimensional physics‐based simulation, and template design for directed self‐assembly (DSA). Guided by experimental data, AI‐assisted calibration accelerates model optimization, supports morphology prediction, and identifies template windows.
Caiwei Shang   +9 more
wiley   +1 more source

Enriched Soil Organic Carbon Underpins Long‐Term Stable Crop Productivity Across China's Croplands

open access: yesAdvanced Science, EarlyView.
Quantifying the nonlinear relationships and causal effects of soil organic carbon (SOC) on crop stability reveals specific critical thresholds and saturation points. This partitions the national SOC spectrum into three functional phases. Integrating these spatial delineations with high‐resolution maps of marginal gains pinpoints regions with the ...
Yuyang Huang   +11 more
wiley   +1 more source

BRCA1 Mutation‐Recognizing Tetrahedral Framework Nucleic Acid Nanoplatform Enables Coordinated PARP/WEE1 Inhibition and STING‐Associated Antitumor Immunity in Ovarian Cancer

open access: yesAdvanced Science, EarlyView.
BRCA1 mutation‐responsive FBOA‐tFNA selectively recognizes mutant transcripts and coordinates reduction‐responsive intracellular delivery of olaparib and adavosertib, amplifying DNA damage and weakening G2/M checkpoint protection. These effects are accompanied by STING‐associated immune activation and stronger antitumor immunity, while sequential anti ...
Chenyi Wang   +7 more
wiley   +1 more source

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