Results 21 to 30 of about 451,740 (266)

Real life efficacy of palbociclib and endocrine therapy in HR positive, HER2 negative advanced breast cancer

Breast, 2020
Background: Palbociclib is indicated for the treatment of hormone receptor-positive (HR+), HER2-negative (HER2-) advanced breast cancer (ABC), in combination with endocrine therapy. Emerging real-life data suggest that the efficacy of a palbociclib-based
B. Porte, M. Carton, F. Lerebours, E. Brain, D. Loirat, L. Haroun, A. Bellesoeur, S. Bach Hamba, Y. Kirova, P. Cottu   +9 more
doaj   +1 more source

Ad hoc Cloud computing [PDF]

, 2015
This paper presents the first complete, integrated and end-to-end solution for ad hoc cloud computing en- vironments. Ad hoc clouds harvest resources from existing sporadically available, non-exclusive (i.e.
Barker, Adam David, Atkinson, Malcolm, Gary A. McGilvary, Adam Barker, Malcolm Atkinson, McGilvary, Gary, Barker, Adam   +6 more
core   +1 more source

Cloud Services Brokerage : a survey and research roadmap

, 2015
A Cloud Services Brokerage (CSB) acts as an intermediary between cloud service providers (e.g., Amazon and Google) and cloud service end users, providing a number of value adding services. CSBs as a research topic are in there infancy.
Barker, Adam David, Varghese, Blesson, Adam Barker, Blesson Varghese, Thai, Long Thanh, Long Thai   +5 more
core   +1 more source

Energy and carbon-aware distributed machine learning tasks scheduling scheme for the multi-renewable energy-based edge-cloud continuum

Science and Technology for Energy Transition
As an increasing number of Distributed Machine Learning (DML) tasks are hosted on cloud platforms in the edge-cloud continuum, Data Centers (DCs) with massive data and computational requirements have become one of the world’s largest energy consumers ...
Miao Zicong, Liu Lei, Nan Haijing, Li Weize, Pan Xiaodong, Yang Xin, Yu Mi, Chen Hui, Zhao Yiming   +8 more
doaj   +1 more source

Time for Cloud? Design and implementation of a time-based cloud resource management system

, 2014
The current pay-per-use model adopted by public cloud service providers has influenced the perception on how a cloud should provide its resources to end-users, i.e. on-demand and access to an unlimited amount of resources.
Ko, Ryan K. L., Ng, Grace P. Y., Ryan K.L. Ko, Alan Y.S. Tan, Ng, Grace P.Y., Tan, Alan Y.S., Tan, Alan Y. S., Grace P.Y. Ng, Ko, Ryan K.L.   +8 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods A comparative analysis between digital insoles
Deborah A. Hall, Kimberly Kwei, Rolando J. Acosta, Bharatkumar Koyani, Erin Robertson, Pratyush Rai, Roland Barge, Emily Timm, Nicollette L. Purcell, Natasha Desai, Dhanesh Patel, Ana‐Maria Visoiu‐Knapp, Samuel Stuart, Rinol Alaj, Matthew F. Wipperman, Oren Levy, Joan A. O'Keefe   +16 more
wiley   +1 more source

Clinical utility of circulating tumor cells: an update

Molecular Oncology, 2021
The prognostic role of circulating tumor cells (CTCs) has been clearly demonstrated in many types of cancer. However, their roles in diagnostic and treatment strategies remain to be defined.
Antoine Vasseur, Nicolas Kiavue, François‐Clément Bidard, Jean‐Yves Pierga, Luc Cabel   +4 more
doaj   +1 more source

¹⁸F-FDG PET/CT in Relapsed Endometrial Cancer Treated with Preoperative PD-1 Inhibitor Dostarlimab

Diagnostics, 2021
Dostarlimab is an immune checkpoint inhibitor (ICI) targeting the Programmed-Death-1 (PD-1) co-receptor, recently approved by the European Medicines Agency (EMA) and the Food and Drug Administration (FDA) as a novel therapy for recurrent or advanced ...
Romain-David Seban, Anne Donnadieu, Gabrielle Journo, Francois-Clement Bidard, Capucine Richard, Roman Rouzier, Laurence Champion   +6 more
doaj   +1 more source