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Clozapine Intoxication in COVID-19.
American Journal of Psychiatry, 2021Presents a case report of a 46-year-old Caucasian nonsmoker, lives at an institution for people with intellectual disabilities He is known to have a severe intellectual disability of unknown cause as well as schizophrenia, for which he takes 200 mg of ...
Niels Tio, P. Schulte, H. Martens
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Tijdschrift voor Geneeskunde, 2000
Schizofrene psychose treedt op in 0,3 tot 0,6% van de bevolking, ontstaat meestal op jongere leeftijd en kent ondanks de huidige therapeutische mogelijkheden een slechte prognose. Clozapine, een atypisch neurolepticum, kwam sinds de studie van Kane et al. in 1988 opnieuw in de belangstelling aangezien werd aangetoond dat met clozapine een therapeutisch
Vanderbruggen, Nathalie, Peuskens, Jozef
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Schizofrene psychose treedt op in 0,3 tot 0,6% van de bevolking, ontstaat meestal op jongere leeftijd en kent ondanks de huidige therapeutische mogelijkheden een slechte prognose. Clozapine, een atypisch neurolepticum, kwam sinds de studie van Kane et al. in 1988 opnieuw in de belangstelling aangezien werd aangetoond dat met clozapine een therapeutisch
Vanderbruggen, Nathalie, Peuskens, Jozef
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Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine.
Archives of General Psychiatry, 1988The treatment of schizophrenic patients who fail to respond to adequate trials of neuroleptics is a major challenge. Clozapine, an atypical antipsychotic drug, has long been of scientific interest, but its clinical development has been delayed because of
J. Kane +3 more
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Current Medical Research and Opinion, 2001
Clozapine is a dibenzodiazepine derivative and a truly atypical anti-psychotic. Its therapeutic effects are probably mediated by dopaminergic and serotonergic activity. Although it appears to be the most effective antipsychotic drug for treatment-resistant schizophrenia, its general use is limited because of the risk of agranulocytosis.
Ben Green, Miriam Naheed
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Clozapine is a dibenzodiazepine derivative and a truly atypical anti-psychotic. Its therapeutic effects are probably mediated by dopaminergic and serotonergic activity. Although it appears to be the most effective antipsychotic drug for treatment-resistant schizophrenia, its general use is limited because of the risk of agranulocytosis.
Ben Green, Miriam Naheed
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Systematic review and meta-analysis of rates of clozapine-associated myocarditis and cardiomyopathy
Australian and New Zealand journal of psychiatry (Print), 2020Background: Clozapine is the most effective medication for treatment refractory schizophrenia, but is associated with cardiac adverse drug reactions. Myocarditis and cardiomyopathy are the most serious cardiac adverse drug reactions although reported ...
D. Siskind +6 more
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Biological Psychiatry, 1995
Epileptiform EEG changes, myoclonus, and seizures are reported in some patients treated with clozapine. Although these are undesirable side effects, the excitation of specific neuronal networks by clozapine and other neuroleptics may be important for the therapeutic effect of this class of agents. In these experiments, intraperitoneal clozapine 2-16 mg/
Duane Denney, Janice R. Stevens
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Epileptiform EEG changes, myoclonus, and seizures are reported in some patients treated with clozapine. Although these are undesirable side effects, the excitation of specific neuronal networks by clozapine and other neuroleptics may be important for the therapeutic effect of this class of agents. In these experiments, intraperitoneal clozapine 2-16 mg/
Duane Denney, Janice R. Stevens
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Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1991
Clozapine is a neuroleptic agent whose structure consists of a dibenzodiazepine derivative with a piperazinyl side chain. It has been classified as an atypical neuroleptic drug due to its unique neuropharmacologic profile. Clozapine has a weak binding affinity for dopamine D‐1 and D‐2 receptors by its slightly greater preference for D‐1 receptors, as ...
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Clozapine is a neuroleptic agent whose structure consists of a dibenzodiazepine derivative with a piperazinyl side chain. It has been classified as an atypical neuroleptic drug due to its unique neuropharmacologic profile. Clozapine has a weak binding affinity for dopamine D‐1 and D‐2 receptors by its slightly greater preference for D‐1 receptors, as ...
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Pharmacological investigations of clozapine and clozapine analogues
2021This thesis was scanned from the print manuscript for digital preservation and is copyright the author. Researchers can access this thesis by asking their local university, institution or public library to make a request on their behalf. Monash staff and postgraduate students can use the link in the Reference field.
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