The FASEB Journal, Volume 39, Issue 17, 15 September 2025.After chemotherapy, blood cell numbers initially decrease but later recover as hematopoietic progenitor cells increase. Following chemotherapy, RBC concentrations in bone marrow peaked at day 5, and direct contact between HSCs and RBCs increased. This contact induced elevated expression of Notch1 and Hes1 in HSCs. Hes1‐deficient HSCs and treatment with
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