Results 51 to 60 of about 8,707 (213)

Payload‐Based Clinical Pharmacology Review of Approved Antibody–Drug Conjugates: Commonalities and Considerations for Streamlined Development

Clinical Pharmacology &Therapeutics, EarlyView.
Antibody–drug conjugates (ADCs) combine the specificity of an antibody with the potency of a cytotoxic drug. Thirteen ADCs, utilizing seven unique cytotoxic payloads and targeting 11 distinct antigens, are currently approved by the US Food and Drug Administration as of June 2025, representing a rapidly growing and highly promising class of anticancer ...
Sijie Lu, Qingqing Xiao, Lixuan Qian, Siyuan Sun, Zhu Zhou, Michael Z. Liao, Chunze Li   +6 more
wiley   +1 more source

Preschoolers' Early Sentence Comprehension: Comparing Bilingual and Monolingual Children and the Role of Executive Function and Vocabulary Development. [PDF]

Dev Sci
ABSTRACT Previous research into children's comprehension of syntactic structures has investigated early awareness of transitive and intransitive structures amongst monolingual children but research into bilingual children's understanding of the same sentence structures is lacking. This study compared 46 3–5‐year‐old bilingual children who spoke English
Rodenhurst N, Messenger K.
europepmc   +2 more sources

CSR Symbolism in Consumer‐Brand Identification in Fostering Brand Trust and Evangelism

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Based on the construal level theory, we proposed a conceptual model linking the relationships between perceived symbols in CSR communication, consumer‐brand identification, brand trust, and brand evangelism. We collected the data from the U.S. national population and employed an experimental design.
Md Merajur Rahman, Swagata Chakraborty
wiley   +1 more source

One-third of an Archivial Series of Papillary Thyroid Cancer (Years 2007–2015) Has Coexistent Chronic Lymphocytic Thyroiditis, Which Is Associated with a More Favorable Tumor-Node-Metastasis Staging

Frontiers in Endocrinology, 2017
The significance and impact of the coexistence of chronic lymphocytic thyroiditis (CLT) with thyroid cancer is still debated. To verify the influence of CLT on papillary thyroid cancer (PTC), we retrospectively collected 505 PTC cases and analyzed age at
Antonio Ieni, Roberto Vita, Emilia Magliolo, Mariacarmela Santarpia, Flavia Di Bari, Salvatore Benvenga, Salvatore Benvenga, Salvatore Benvenga, Giovanni Tuccari   +8 more
doaj   +1 more source

Multivariate Image Analysis Applied to Cross-Laminated Timber: Combined Hyperspectral Near-Infrared and X-ray Computed Tomography

Journal of Spectroscopy, 2023
Engineered wood products, such as cross-laminated timber (CLT), are becoming more popular in the designs of modern sustainable buildings. This increased production of CLT requires more robust, yet less labour-intensive means to assess the material ...
Dietrich Buck, Olle Hagman
doaj   +1 more source

Effects of Wall‐to‐Floor Interactions on Seismic Response of Platform‐Type CLT Buildings

Earthquake Engineering &Structural Dynamics, EarlyView.
ABSTRACT Platform‐type cross‐laminated timber (CLT) buildings feature discontinuous wall segments supported by CLT floors. In practice, CLT floors are often treated as rigid diaphragm, yet the wall‐to‐floor interactions (WFIs) associated with flexibility of floors remain insufficiently investigated during seismic performance assessment.
Chaoyue Zhang, Yuxin Pan, Jiawei Chen, Huifeng Yang   +3 more
wiley   +1 more source

Char Layer Thickness Evolution During Structural Timber Fire Experiment and Final Density Profile

Fire and Materials, EarlyView.
ABSTRACT This paper evaluates several non‐destructive experimental methods for determining the char layer thickness and its density profile in structural timber samples exposed to standard ISO 834 fire curve experiments. Microwave echo pulse, ultrasonic echo pulse, X‐ray computed tomography, and resistance drilling were evaluated.
Fernando Pérez Pérez, Kiarash Tajbakhsh, Joachim Schmid, Robert Zboray, Andrea Frangi   +4 more
wiley   +1 more source

From Classical to Modern Nonlinear Central Limit Theorems

Mathematics
In 1733, de Moivre, investigating the limit distribution of the binomial distribution, was the first to discover the existence of the normal distribution and the central limit theorem (CLT).
Vladimir V. Ulyanov
doaj   +1 more source

An Experimental Investigation on the Impact of Burner Height and Location on the Characteristics of Externally Venting Flames

Fire and Materials, EarlyView.
ABSTRACT Fire sources in actual compartment fires exhibit a predominantly uneven spatial distribution. In this context, the impact of the height and location of the fire source, as well as the heat release rate (HRR) of the fire, on the thermal characteristics of Externally Venting Flames (EVF) is experimentally investigated.
Dionysios I. Kolaitis, Andrianos E. Koklas   +1 more
wiley   +1 more source

Influence of Adhesive Type on Heat Induced Delamination in Tension Loaded Shear Lap Cross‐Laminated Timber Samples Exposed to Radiant Heat Flux

Fire and Materials, EarlyView.
ABSTRACT Heat induced delamination (HID) is a phenomenon in engineered wood products which may result in the detachment of the bonded timber lamellae before charring propagates to the bond line interphase. This study aims to correlate the thermal degradation of two 1‐c‐polyurethane adhesives at the microscale to the thermo‐hydro‐mechanical behaviour of
A. Čolić, F. Wiesner, M. Spearpoint, D. Hopkin, L. Bisby   +4 more
wiley   +1 more source