Results 101 to 110 of about 31,615 (293)

Trackable Tolerogenic Macrophages Integrate PD‐L1 and Rapamycin Signaling to Suppress Alloimmune Responses in Transplantation

Advanced Science, EarlyView.
We developed a macrophage‐based therapeutic platform, termed trackable tolerogenic macrophages (TTM), for dual‐function immunomodulation and visualization in vivo. TTM cells were engineered to overexpress PD‐L1, incorporate bioorthogonal cell surface tags, and load rapamycin for sustained release.
Yihui Wang, Yuan Song, Yuji Xie, Junmin Zhang, Jing Liu, Wenyuan Wang, Ying Xu, Wenqian Wu, Wuqi Zhou, Qiaofeng Jin, Jing Wang, Yali Yang, Li Zhang, Tang Gao, Mingxing Xie   +14 more
wiley   +1 more source

Instabilities in the Envelopes and Winds of Very Massive Stars

, 2014
The high luminosity of Very Massive Stars (VMS) means that radiative forces play an important, dynamical role both in the structure and stability of their stellar envelope, and in driving strong stellar-wind mass loss.
A. A. Belyanin, A. Feldmeier, A. Feldmeier, A. J. Marle van, A. Pauldrach, A. S. Eddington, A. W. Fullerton, C. A. Iglesias, C. D. Levermore, C. F. Gammie, D. F. Figer, D. H. Cohen, E. A. Spiegel, E. A. Spiegel, E. A. Spiegel, E. T. Vishniac, G. C. Pomraning, J. Arons, J. C. B. Papaloizou, J. I. Castor, J. O. Sundqvist, J. O. Sundqvist, J. Petrovic, K. B. MacGregor, K. G. Gayley, L. B. Lucy, L. B. Lucy, L. Dessart, L. M. Oskinova, M. C. Begelman, M. C. Runacres, M. S. Oey, N. Grevesse, N. J. Shaviv, N. J. Shaviv, N. J. Shaviv, N. Smith, N. Smith, N. Smith, O. Blaes, P. A. Crowther, P. C. Joss, R. Kippenhahn, R. P. Kudritzki, S. P. Owocki, S. P. Owocki, S. P. Owocki, S. P. Owocki, S. P. Owocki, S. P. Owocki, T. Quinn, V. V. Sobolev, W. Glatzel, W. Glatzel   +53 more
core   +1 more source

PROTAC‑Mediated HMGCR Depletion Reprograms Lipid Metabolism in Breast Cancer to Potentiate Photoimmunotherapy via Ferroptosis

Advanced Science, EarlyView.
This work introduces a study that identifies HMGCR as a novel target in TNBC and develops a light‐gated PROTAC nanomedicine. Upon irradiation, this agent selectively degrades HMGCR, reprogramming lipid metabolism to induce ferroptosis and potent antitumor immunity, thereby significantly enhancing photoimmunotherapy efficacy.
Tong Su, Guang Li, Yudong Guan, Qi Tian, Youzhi Qi, Yanqiu Zhang, Wenqian Wei, Xinxin Duan, Jiaxin Rui, Hongyan Zhu, Zengping Lin, Changchuan Xie, Zheni Xu, Yaying Wu, Xin Peng, Zhenjie Wang, Kun Chen, Xiaoyan Xin, Bing Zhang   +18 more
wiley   +1 more source

Reconfigurable Acoustofluidic Microvortices for Selective Microcargo Delivery

Advanced Science, EarlyView.
This work introduces a frequency‐encoded, reconfigurable acoustofluidic system that overcomes the low throughput and poor selectivity of conventional micro‐delivery methods. By exploiting discrete microbubble resonances to program adaptive microvortex modes, the platform enables real‐time switching and selective guidance of microscale payloads through ...
Lei Wang, Yiqiang Wu, Yiyang Tang, Hui Wei, Tianshi Lyu, Xin Zhang, Tian‐Yun Huang   +6 more
wiley   +1 more source

Digital hemispherical photography for estimating forest canopy properties: current controversies and opportunities

iForest - Biogeosciences and Forestry, 2012
Hemispherical photography has been used since the 1960s in forest ecology. Nevertheless, specific constraints related to film cameras have progressively prevented widespread adoption of this photographic method.
Chianucci F, Cutini A
doaj   +1 more source

Implications of WMAP Observations On the Population III Star Formation Processes

, 2003
In an earlier paper (Cen 2003) we pointed out the strong likelihood for the universal reionization to occur twice, giving rise to a larger Thomson optical depth.
Glatzel W., Renyue Cen
core   +3 more sources

Self‐Healing Starch‐Based Ionogels with Hydroneutral Dipole–Dipole Interactions

Advanced Science, EarlyView.
This work introduces starch‐based, conductive, underwater‐healable, and transparent ionogels for soft electronics (SCUTEs). Starch macromolecules are partially substituted with cyanoethyl groups and incorporated with hydrophobic ionic liquid. The polar yet hydroneutral cyanoethyl groups facilitate strong dynamic dipole–dipole interactions that remain ...
J. Justin Koh, Jiayi Liu, Xue Qi Koh, Binting Huang, Szu Cheng Lai, Jayce Jian Wei Cheng, Gwendolyn J. H. Lim, Warintorn Thitsartarn, Yong‐Wei Zhang, Zhigen Yu, Chaobin He   +10 more
wiley   +1 more source

Digital Evaluation of Cigarette Smoke Clumping Based on Aerosol Particle Analysis

IEEE Access
Cigarette smoke clumping, an important indicator of smoke status, draws consumer attention due to its correlation with smoke concentration, thickness, fullness, and the clumping index, which significantly affects the sensory quality of cigarettes. Due to
Lei Jiao, Shishuan Guan, Kezhi Wu, Xiaofei Ji, Cunfeng Yu, Xinlong Zhang, Zengyu Wang, Shuaishuai Sun, Hongtao Li, Liwen Zheng, Jun Li, Guangwei Jiang, Qiang Sun, Erge Lin, Hongwei Zheng   +14 more
doaj   +1 more source

Uncertainty Analysis in the Creation of a Fine-Resolution Leaf Area Index (LAI) Reference Map for Validation of Moderate Resolution LAI Products

Remote Sensing, 2015
The validation process for a moderate resolution leaf area index (LAI) product (i.e., MODIS) involves the creation of a high spatial resolution LAI reference map (Lai-RM), which when scaled to the moderate LAI resolution (i.e., > 1 km) allows for ...
John S. Iiames, Russell G. Congalton, Timothy E. Lewis, Andrew N. Pilant   +3 more
doaj   +1 more source

Towards Climate Neutrality by 2050: Role of Aluminum for Short‐ and Long‐Term Energy and Hydrogen Storage

Advanced Energy Materials, EarlyView.
The Aluminum energy storage cycle involves the use of renewable energy for Al production and the generation of heat (dry cycle) and heat and H2 (wet cycle) for energy production via Al‐steam combustion. ABSTRACT Reaching climate neutrality by 2050 requires innovative long‐term energy storage (LTES) solutions beyond the current use of fossil fuels ...
Lorenzo Trombetti, Stefano Passerini, Linda Barelli   +2 more
wiley   +1 more source