Results 161 to 170 of about 11,335 (270)

Paternal Exposure to the Neonicotinoid Pesticide Clothianidin Alters Sperm MicroRNA Profiles in Mice and Intergenerationally Reduces Locomotor Activity in Male Offspring

Journal of Applied Toxicology, EarlyView.
ABSTRACT Accumulating evidence suggests that paternal environmental factors have epigenetic effects on sperm and influence offspring. Neonicotinoid pesticides (NNs), which are widely used around the world, are known to affect offspring phenotypes through maternal exposure in mice, but the effect of the paternal exposure remains unknown.
Makiko Ito, Tetsushi Hirano, Sarika Nunobiki, Ayano Yoshimoto, Yukako Hara, Yuya Ishida, Sakura Yonoichi, Youhei Mantani, Toshifumi Yokoyama, Yoshiaki Tabuchi, Yoshinori Ikenaka, Nobuhiko Hoshi   +11 more
wiley   +1 more source

Influence of Tonsillectomy on Various Disease Outcomes: An Outcome-wide Association Analysis and Mendelian Randomization Analysis. [PDF]

J Otolaryngol Head Neck Surg
Li J, Qiu K, An P, Zhang Y, Zhang Z, Feng L, Li S, Liang Y, Cheng D, Rao Y, Pang W, Song Y, Mao M, Shu T, Shao X, Yu R, Zheng Y, Xu W, Zhao Y, Ren J.   +19 more
europepmc   +1 more source

Causal Interplay Between Inflammatory Cytokines and Lipid Metabolites in Serous Ovarian Carcinoma: Insights From a Genetic Association Study

Journal of Clinical Laboratory Analysis, EarlyView.
This study utilizes a two‐sample Mendelian randomization framework to establish a causal link between circulating inflammatory proteins, blood metabolites, and the risk of serous ovarian carcinoma. Our findings identify Interleukin‐8 as a significant risk factor and demonstrate that 1‐Palmitoyl‐GPG (16:0) acts as a metabolic mediator within this ...
Chong‐ze Yang, Lan‐hui Qin, Cheng‐can Huang, Xiao‐li Huang, Ying‐xia Yang, Wei Lan, Miao Fan   +6 more
wiley   +1 more source

Young adult self‐harm: The role of victimisation and polygenic risk in a population‐based longitudinal study

JCPP Advances, EarlyView.
Abstract Background Victimisation has been associated with self‐harm (with or without suicidal intent), but little is known about this association during young adulthood—a distinct developmental period. Further, not all individuals who experience victimisation will later engage in self‐harm, suggesting the influence of other factors.
Filip Marzecki, Isabelle Ouellet‐Morin, Helena M. S. Zavos, Sylvana Côté, Richard E. Tremblay, Jean‐Philippe Gouin, Massimiliano Orri, Michel Boivin, Marie‐Claude Geoffroy   +8 more
wiley   +1 more source

An efficient LASSO framework for admixture-aware polygenic scores. [PDF]

HGG Adv
Ockerman F, Chen BD, Sun Q, Kharitonova EV, Chen C, Zhou LY, Loos RJF, Kooperberg C, Peters U, Haessler J, Reiner AP, Jung SY, Manson JE, Nassir R, North KE, Buyske S, Haiman CA, Conti DV, Wilkens LR, Lange EM, Cox NJ, Cao H, Raffield LM, Li Y, Tao R.   +24 more
europepmc   +1 more source

Estimation of gap fraction and clumping index with Terrestrial and Airborne Laser Scanner data

, 2014
El dosel forestal es una zona de intercambio de flujos y energía entre la superficie de la tierra y la atmósfera. Su estructura está representada por la organización espacial de todos los elementos vegetales que se encuentran sobre la superficie. La estructura del dosel condiciona una serie de variables microclimáticas en el interior de este espacio ...
openaire   +1 more source

Unpacking early risks for peer victimization: A network analysis of early temperament and polygenic risk scores

JCPP Advances, EarlyView.
Abstract Background Children who show difficult temperament are at risk of peer victimisation, which in turn associates with numerous negative outcomes later in life. We used network analysis to examine whether specific aspects of difficult temperament contributed to these associations, and whether the links were moderated by variations in genetic ...
Tom C.‐H. Wu, Deniz Konac, Liliana Garcia‐Mondragon, Alex F. Martin, Barbara Maughan, Ted Barker   +5 more
wiley   +1 more source

Leveraging genetic propensity to identify modifiable factors for the age at onset of Alzheimer's disease. [PDF]

Alzheimers Dement
Li YJ, La JO, Naj A, Martin ER.
europepmc   +1 more source

Isolating transdiagnostic effects reveals specific genetic profiles in psychiatric disorders

JCPP Advances, EarlyView.
Abstract Background Evidence indicates substantial genetic overlap between psychiatric diagnoses. Accounting for these transdiagnostic effects can sharpen research on disorder‐specific genetic architecture and patterns of comorbidity. Methods We applied genomic structural equation modeling to genome‐wide association study summary statistics from 11 ...
Engin Keser, Wangjingyi Liao, Andrea G. Allegrini, Kaili Rimfeld, Thalia C. Eley, Robert Plomin, Margherita Malanchini   +6 more
wiley   +1 more source

Causal and shared genetic insights into severe COVID-19 and idiopathic pulmonary fibrosis. [PDF]

iScience
Lin S, Dang X, Kou X, Zhang X, Ding X, Li X.   +5 more
europepmc   +1 more source