Results 141 to 150 of about 10,963 (248)

Pathway-specific polygenic risk scores for blood pressure traits in a West African cohort. [PDF]

Front Cardiovasc Med
Bormes G, Robbin V, Chikowore T, Zhang Y, Choudhury A, Hazelhurst S, Hanchard NA, Adebamowo SN, Adeyemo AA, Tayo B.   +9 more
europepmc   +1 more source

Hematological and Genotoxic Effects of Subchronic Oral Exposure to a Mancozeb‐Based Fungicide in Female Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT The extensive use of pesticides in modern agriculture has raised increasing concerns regarding the potential biological effects of repeated exposure to pesticide residues and commercial formulations. Mancozeb is a widely used ethylene‐bis‐dithiocarbamate fungicide; however, information on its hematological and genotoxic effects following ...
Matheus Henrique Barcelos Figueiredo, Natanael Vaz Crisóstomo Peixoto, Paula Soares Nakamura, Cecília Müller Wodzik, Lucas Ribeiro Maia dos Santos, Fábio Vieira de Andrade Borges, Lara Cândida de Sousa Machado, Jéssica Gardone Vitório, Renata Mazaro e Costa, Mônica Rodrigues Ferreira Machado, Walter Dias Júnior   +10 more
wiley   +1 more source

Influence of Tonsillectomy on Various Disease Outcomes: An Outcome-wide Association Analysis and Mendelian Randomization Analysis. [PDF]

J Otolaryngol Head Neck Surg
Li J, Qiu K, An P, Zhang Y, Zhang Z, Feng L, Li S, Liang Y, Cheng D, Rao Y, Pang W, Song Y, Mao M, Shu T, Shao X, Yu R, Zheng Y, Xu W, Zhao Y, Ren J.   +19 more
europepmc   +1 more source

Low‐Dose Chlorothalonil Induces Testicular Injury Through Disruption of Steroidogenic Signaling in Adult Male Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT Chlorothalonil (CHL) is a widely used organochlorine fungicide frequently detected in environmental and food matrices. Although increasing evidence indicates adverse effects in nontarget species, the mechanisms underlying CHL‐induced male reproductive toxicity remain incompletely understood.
Cristiana Livramento Oliveira Pinto, Nicoly Caixêta Gonçalves, Paula Rafaela Queiroz da Silva, Ludmila Rodrigues Pontes, Juliana Reis Machado, Virmondes Rodrigues Jr., Hugo Felix Perini, Gláucia Eloisa Munhoz de Lion Siervo   +7 more
wiley   +1 more source

Polygenic Risk Scores for Incident Dementia in the Multi-Ethnic Study of Atherosclerosis. [PDF]

Genet Epidemiol
Xue D, Blue EE, Sofer T, Hughes TM, Rotter JI, Post WS, Fohner AE.   +6 more
europepmc   +1 more source

Optimization of Reflex Testing Rules on the Sysmex XN‐9100 Automated Hematology Line Improves Efficiency and Reduces Repeat Testing in Different Work Areas

Journal of Clinical Laboratory Analysis, EarlyView.
This graphical abstract summarizes a workflow‐based Reflex rule optimization for the Sysmex XN‐9100 automated hematology line. A total of 78,364 routine complete blood count samples were analyzed by middleware simulation. The optimized strategy differentiated initial from follow‐up visit samples, incorporated 7‐day historical fluctuation thresholds ...
Lianhui Yu, Min Zhang, Jianying Li, Ping Deng, Haoting Zhan, Wei Wu   +5 more
wiley   +1 more source

An efficient LASSO framework for admixture-aware polygenic scores. [PDF]

HGG Adv
Ockerman F, Chen BD, Sun Q, Kharitonova EV, Chen C, Zhou LY, Loos RJF, Kooperberg C, Peters U, Haessler J, Reiner AP, Jung SY, Manson JE, Nassir R, North KE, Buyske S, Haiman CA, Conti DV, Wilkens LR, Lange EM, Cox NJ, Cao H, Raffield LM, Li Y, Tao R.   +24 more
europepmc   +1 more source

Development and Analytical Validation of a Laboratory‐Customized TaqMan‐MGB Probe Method for CYP2C19 Genotyping

Journal of Clinical Laboratory Analysis, EarlyView.
A laboratory‐customized, open‐sequence TaqMan‐MGB probe assay was developed for detecting CYP2C19*2 and CYP2C19*17 polymorphisms using dried blood spot‐derived DNA. The assay demonstrated allele‐specific discrimination, candidate LODs of 1.17 × 102 copies/μL for CYP2C19*2 and 0.94 × 103 copies/μL for CYP2C19*17, and repeatability with CVs below 10%. In
Yaqun Liu, Lianghui Chen, Xuanyi Zheng, Peikui Yang, Yicun Chen, Chengsong Xie, Zhenxia Zhang, Yuzhong Zheng   +7 more
wiley   +1 more source

Leveraging genetic propensity to identify modifiable factors for the age at onset of Alzheimer's disease. [PDF]

Alzheimers Dement
Li YJ, La JO, Naj A, Martin ER.
europepmc   +1 more source

Optimizing Laboratory Autoverification in Complete Blood Count Testing Using Machine Learning: A Performance Evaluation Study

Journal of Clinical Laboratory Analysis, EarlyView.
This cross‐sectional study evaluated the feasibility of applying machine learning for complete blood count autoverification. Among 63,201 CBC results, the XGBoost model achieved higher sensitivity and predictive values compared with the traditional rule‐based system. ABSTRACT Background Autoverification improves laboratory efficiency by reducing manual
Sinsorn Srirujee, Peempol Chokchaipermpoonphol   +1 more
wiley   +1 more source