Results 91 to 100 of about 158,776 (309)

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Prehospital Randomised Assessment of a Mechanical Compression Device In Cardiac Arrest (PaRAMeDIC) Trial Protocol [PDF]

, 2010
BACKGROUND Survival after out-of-hospital cardiac arrest is closely linked to the quality of CPR, but in real life, resuscitation during prehospital care and ambulance transport is often suboptimal.
Anne Slowther, Charles Deakin, Chris McCabe, Gavin D Perkins, Jessica Horton, Malcolm Woollard, Matthew W Cooke, Ranjit Lall, Sarah E Lamb, Simon Gates, Tom Quinn   +10 more
core   +5 more sources

Preventing suicidal behaviours with a multilevel intervention: a cluster randomised controlled trial [PDF]

BMC Public Health, 2018
In the context of the recent surge in community based multilevel interventions for suicide prevention, all of which show promising results, we discuss the implications of the findings of such an intervention designed for and implemented in New Zealand. The multi-level intervention for suicide prevention in New Zealand (MISP-NZ) was a cluster randomised
Collings, Sunny, Jenkin, Gabrielle, Stanley, James, McKenzie, Sarah, Hatcher, Simon   +4 more
openaire   +4 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Recommendations for the analysis of individually randomised controlled trials with clustering in one arm – a case of continuous outcomes

BMC Medical Research Methodology, 2016
Background In an individually randomised controlled trial where the treatment is delivered by a health professional it seems likely that the effectiveness of the treatment, independent of any treatment effect, could depend on the skill, training or even ...
Laura Flight, Annabel Allison, Munyaradzi Dimairo, Ellen Lee, Laura Mandefield, Stephen J. Walters   +5 more
doaj   +1 more source

Supporting carers to manage pain medication in cancer patients at the end of life: A feasibility trial [PDF]

, 2017
Background: Carers of people with advanced cancer play a significant role in managing pain medication, yet they report insufficient information and support to do so confidently and competently. There is limited research evidence on the best ways for
Alison Richardson, Anderson BA, Bandura A, Bee P, Campbell NC, Carl May, Cleeland CS, Curran SL, Donovan HS, Elizabeth Lowson, Hopkinson J, Hudson PL, Jacki Hughes, Jane A Hughes, Jane B Hopkinson, Kazanowski M, Klepstad P, Lancaster G, Latter S, Latter S, Lawton J, Lazarus RS, Lee L, Letizia M, Lin C, Mehta A, Michael I Bennett, Moorey S, Oldham L, Patton MQ, Payne S, Peter Smith, Ritchie J, Robinson B, Sally Anstey, Schumacher K, Stone PC, Sue Duke, Sue Latter, Sygna K, Teunissen SCCM, Woodman C, Zeiss AM   +42 more
core   +5 more sources

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

A scoping review of the problems and solutions associated with contamination in trials of complex interventions in mental health

BMC Medical Research Methodology, 2019
Background In a randomised controlled trial, contamination is defined as the receipt of active intervention amongst participants in the control arm.
Nicholas Magill, Ruth Knight, Paul McCrone, Khalida Ismail, Sabine Landau   +4 more
doaj   +1 more source

Raising the standard of applied dementia care research : addressing the implementation error [PDF]

, 2014
Editoria
Moniz-Cook, Esme, Vernooij-Dassen, Myrra
core   +2 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source