Results 1 to 10 of about 184,908 (263)

The APPLE Tree programme: Active Prevention in People at risk of dementia through Lifestyle, bEhaviour change and Technology to build REsiliEnce—randomised controlled trial

Trials, 2022
Background Large-scale trials of multidomain interventions show that modifying lifestyle and psychological risk factors can slow cognitive decline. We aim to determine if a lower intensity, personally tailored secondary dementia prevention programme for ...
M. Poppe, L. Duffy, N. L. Marchant, J. A. Barber, R. Hunter, N. Bass, A. M. Minihane, K. Walters, P. Higgs, P. Rapaport, I. A. Lang, S. Morgan-Trimmer, J. Huntley, Z. Walker, H. Brodaty, H. C. Kales, K. Ritchie, A. Burton, J. Wenborn, A. Betz, C. Cooper   +20 more
doaj   +1 more source

Adapting the randomised controlled trial (RCT) for precision medicine: introducing the nested-precision RCT (npRCT)

Trials, 2021
Adaptations to the gold standard randomised controlled trial (RCT) have been introduced to decrease trial costs and avoid high sample sizes. To facilitate development of precision medicine algorithms that aim to optimise treatment allocation for ...
Nils Kappelmann, Bertram Müller-Myhsok, Johannes Kopf-Beck   +2 more
doaj   +1 more source

Latch On: A protocol for a multi-centre, randomised controlled trial of perinatal support to improve breastfeeding outcomes in women with a raised BMI

Contemporary Clinical Trials Communications, 2021
Introduction: Breastfeeding is associated with improved maternal and child outcomes. Women with a higher body mass index (BMI), who comprise about 50% of the population, are at increased risk of poorer breastfeeding practices and are a population who ...
Sharleen L. O'Reilly, Eileen C. O'Brien, Denise McGuinness, John Mehegan, Barbara Coughlan, Denise O'Brien, Marcelina Szafranska, Sophie Callanan, Shenda Hughes, Marie C. Conway, Mary Brosnan, Lucille Sheehy, Rosie Murtagh, Lorraine O'Hagan, Stephanie Murray, Charmaine Scallon, Elizabeth Dunn, Paula Power, Marie Woodcock, Amy Carroll, Marie Corbett, Michelle Walsh, Regina Keogh, Fionnuala M. McAuliffe   +23 more
doaj   +1 more source

Optimising recruitment to the HAND-1 RCT feasibility study: integration of the QuinteT Recruitment Intervention (QRI)

Pilot and Feasibility Studies, 2020
Background Recruitment to randomised controlled trials (RCTs) can be challenging, with most trials not reaching recruitment targets. Randomised feasibility studies can be set up prior to a main trial to identify and overcome recruitment obstacles.
Samantha Husbands, Daisy Elliott, Tim R. C. Davis, Jane M. Blazeby, Eleanor F. Harrison, Alan A. Montgomery, Kirsty Sprange, Lelia Duley, Alexia Karantana, William Hollingworth, Nicola Mills   +10 more
doaj   +1 more source

The impact of video gaming on cognitive functioning of people with schizophrenia (GAME-S): study protocol of a randomised controlled trial

BMC Psychiatry, 2021
Background Video gaming is a promising intervention for cognitive and social impairment in patients with schizophrenia. A number of gaming interventions have been evaluated in small-scale studies with various patient groups, but studies on patients with ...
Maritta Välimäki, Min Yang, Yuen Ting Joyce Lam, Tella Lantta, Matias Palva, Satu Palva, Benjamin Yee, Siu Hung Yip, Kin-sun Dan Yu, Hing Chiu Charles Chang, Po Yee Ivy Cheng, Daniel Bressington   +11 more
doaj   +1 more source

Design considerations for clinical trials in aphasia

Annals of Indian Academy of Neurology, 2020
The use of the randomised controlled trial (RCT) design to evaluate the effectiveness of new interventions in aphasia has increased in recent years in response to calls for high quality evidence of the effectiveness of interventions for this population ...
Rebecca Palmer
doaj   +1 more source

Seminal papers in urology: maintenance Bacillus Calmette-Guerin (BCG) immunotherapy for recurrent Ta, T1 and carcinoma in situ transitional cell carcinoma of the bladder: a randomized southwest oncology group study (SWOG-8507)

BMC Urology, 2023
The South West Oncology Group’s 2000 randomised-control trial investigated the addition of maintenance intravesical bacillus Calmette-Guerin (BCG) to non-muscle invasive urothelial carcinoma (NMIUC) treatment. The results were published when the efficacy
Jake Tempo, Damien Bolton, Michael O’Callaghan   +2 more
doaj   +1 more source

Household costs of dengue illness: secondary outcomes from a randomised controlled trial of dengue prevention in Guerrero state, Mexico

BMC Public Health, 2017
Background Dengue is a serious public health problem with an important economic impact. This study used data from a cluster randomised controlled trial of community mobilisation for dengue prevention to estimate the household costs of treatment of dengue
José Legorreta-Soberanis, Sergio Paredes-Solís, Arcadio Morales-Pérez, Elizabeth Nava-Aguilera, Felipe René Serrano-de los Santos, Diana Lisseth Dimas-Garcia, Robert J Ledogar, Anne Cockcroft, Neil Andersson   +8 more
doaj   +1 more source

Does prospective acceptability of an intervention influence refusal to participate in a randomised controlled trial? An interview study

Contemporary Clinical Trials Communications, 2021
Background: The generalizability of findings of Randomised Controlled Trials (RCTs) is undermined by low or biased recruitment. Reasons for participant refusal are infrequently reported in published literature. Aims: To apply the Theoretical Framework of
Mandeep Sekhon, Martin Cartwright, Sadie Lawes-Wickwar, Hayley McBain, Daniel Ezra, Stanton Newman, Jill J Francis   +6 more
doaj   +1 more source

Enhancing Recruitment Using Teleconference and Commitment Contract (ERUTECC): study protocol for a randomised, stepped-wedge cluster trial within the EFFECTS trial

Trials, 2018
Background Many randomised controlled trials (RCTs) fail to meet their recruitment goals in time. Trialists are advised to include study recruitment strategies within their trials. EFFECTS is a Swedish, academic-led RCT of fluoxetine for stroke recovery.
Erik Lundström, Eva Isaksson, Per Wester, Ann-Charlotte Laska, Per Näsman   +4 more
doaj   +1 more source