Results 1 to 10 of about 185,473 (164)

Early antiviral treatment in outpatients with COVID-19 (FLARE): a structured summary of a study protocol for a randomised controlled trial

Trials, 2021
Objectives The objective of this trial is to assess whether early antiviral therapy in outpatients with COVID-19 with either favipiravir plus lopinavir/ritonavir, lopinavir/ritonavir alone, or favipiravir alone, is associated with a decrease in viral ...
Li-An K. Brown, Nick Freemantle, Judy Breuer, Hakim-Moulay Dehbi, Kashfia Chowdhury, Gemma Jones, Felicia Ikeji, Amalia Ndoutoumou, Krishneya Santhirakumar, Nicky Longley, Anna M. Checkley, Joseph F. Standing, David M. Lowe   +12 more
doaj   +1 more source

Moxibustion for cephalic version: a feasibility randomised controlled trial

BMC Complementary and Alternative Medicine, 2011
Background Moxibustion (a type of Chinese medicine which involves burning a herb close to the skin) has been used to correct a breech presentation.
Bisits Andrew, Dahlen Hannah, Smith Caroline A, Do Carole K, Schmied Virginia   +4 more
doaj   +1 more source

An exploration of the factors influencing successful implementation, delivery and outcomes in an intensive care sedation study: process evaluation of the A2B RCT

Health Technology Assessment
Background Choice of sedation of critically ill patients is a core element of intensive care practice. The alpha 2 agonists for sedation to produce better outcomes from critical illness (A2B) trial tested the effectiveness of two alpha agonist sedatives ...
Leanne M Aitken, Lydia M Emerson, Kalliopi Kydonaki, Bronagh Blackwood, Ben Creagh-Brown, Nazir Lone, Cathrine McKenzie, Richard Parker, Michael C Reade, Christopher J Weir, Matt P Wise, Timothy S Walsh   +11 more
doaj   +1 more source

Effects of stimulating single acupoint and combination acupoints on diabetic gastroparesis: A randomised controlled trial study

Journal of Traditional and Complementary Medicine
Background and aim: The most effective among the acupoints remains to be determined for treating diabetic gastroparesis (DGP). This study aimed to compare single and combination acupoints for their effectiveness in DGP.
Renming Liu, Min He, Xuewei Zhao, Mengmeng Sun, Jiazhen Cao, Xinyue Wang, Xingbang Wang, Shuming Zhao, Fuchun Wang, Tie Li   +9 more
doaj   +1 more source

An optimised patient information sheet did not significantly increase recruitment or retention in a falls prevention study: an embedded randomised recruitment trial

Trials, 2017
Background Randomised controlled trials are generally regarded as the ‘gold standard’ experimental design to determine the effectiveness of an intervention.
Sarah Cockayne, Caroline Fairhurst, Joy Adamson, Catherine Hewitt, Robin Hull, Kate Hicks, Anne-Maree Keenan, Sarah E. Lamb, Lorraine Green, Caroline McIntosh, Hylton B. Menz, Anthony C. Redmond, Sara Rodgers, David J. Torgerson, Wesley Vernon, Judith Watson, Peter Knapp, Jo Rick, Peter Bower, Sandra Eldridge, Vichithranie W. Madurasinghe, Jonathan Graffy   +21 more
doaj   +1 more source

Investigating strategies to improve AccesS to Kidney transplantation (the ASK trial): a protocol for a feasibility randomised controlled trial with parallel process evaluation

Pilot and Feasibility Studies, 2023
Background The UK’s living-donor kidney transplant (LDKT) activity falls behind that of many other countries internationally, with less than 20% of those eligible receiving a LDKT each year.
Pippa K. Bailey, Fergus J. Caskey, Stephanie MacNeill, Rachel Ashford, Lindsay Pryce, Liise Kayler, Yoav Ben-Shlomo   +6 more
doaj   +1 more source

Gefitinib and methotrexate to resolve tubal ectopic pregnancy: the GEM3 RCT

Efficacy and Mechanism Evaluation, 2023
Background Tubal ectopic pregnancies can cause significant morbidity or even death. Current treatment is with methotrexate or surgery. However, methotrexate treatment can fail in approximately 30% of women.
Moakes Catherine A, Tong Stephen, Middleton Lee J, Duncan W Colin, Mol Ben W, Whitaker Lucy H R, Jurkovic Davor, Coomarasamy Arri, Nunes Natalie, Holland Tom, Clarke Fiona, Sutherland Lauren C, Doust Ann M, Daniels Jane P, Horne Andrew W   +14 more
doaj   +1 more source

Randomised controlled trials [PDF]

Postgraduate Medical Journal, 1999
Randomised controlled trials , Alejandro Jadad, pp 128. BMJ Books, 1998. £12.95 (£11.95 to BMA members), paperback. ISBN 0 7279 1208 9. ★★★ The issue of trial design is increasingly recognised as central to the evaluation of the benefit from any healthcare intervention.
openaire   +1 more source

A randomised controlled trial to evaluate and optimize the use of antiplatelet agents in the perioperative management in patients undergoing general and abdominal surgery- the APAP trial (ISRCTN45810007)

BMC Surgery, 2011
Background Due to the increase of cardiovascular diseases acetylsalicylic acid (ASA) has become one of the most frequently prescribed drugs these days.
Rahbari Nuh N, Contin Pietro, Rakow Anastasia, Reissfelder Christoph, Antolovic Dalibor, Büchler Markus W, Weitz Jürgen, Koch Moritz   +7 more
doaj   +1 more source

Physio4FMD: protocol for a multicentre randomised controlled trial of specialist physiotherapy for functional motor disorder

BMC Neurology, 2019
Background Patients with functional motor disorder (FMD) experience persistent and disabling neurological symptoms such as weakness, tremor, dystonia and disordered gait.
Glenn Nielsen, Jon Stone, Marta Buszewicz, Alan Carson, Laura H. Goldstein, Kate Holt, Rachael Hunter, Jonathan Marsden, Louise Marston, Hayley Noble, Markus Reuber, Mark J. Edwards, on behalf of the Physio4FMD Collaborative Group   +12 more
doaj   +1 more source