Results 41 to 50 of about 703,659 (314)

Biomarker-guided implementation of the KDIGO guidelines to reduce the occurrence of acute kidney injury in patients after cardiac surgery (PrevAKI-multicentre): protocol for a multicentre, observational study followed by randomised controlled feasibility trial [PDF]

, 2020
Introduction Acute kidney injury (AKI) is a frequent complication after cardiac surgery with adverse short-term and long-term outcomes. Although prevention of AKI (PrevAKI) is strongly recommended, the optimal strategy is uncertain.
Arndt, Christian, Campos, Sara, Cegarra Sanmartin, Virginia, Di Prima, Ambra, Forni, Lui, García Álvarez, Mercedes, Gerss, Joachim, Grau Novellas, Neus, Grieshaber, Philippe, Haffner, Michael, Honore, Patrick M, Hoste, Eric A J, Irqsusi, Marc, Italiano, Stefano, Kellum, John, Kunst, Gudrun, Küllmar, Mira, L'acqua, Camilla, Massoth, Christina, Meersch, Melanie, Monaco, Fabrizio, Nair, Shrijit, Ostermann, Marlies, Thomson, Gary, Universitat Autònoma de Barcelona, Vandenberghe, Wim, Weiss, Raphael, Wempe, Carola, Wulf, Hinnerk, Zarbock, Alexander   +29 more
core   +2 more sources

Effect of a machine learning-based severe sepsis prediction algorithm on patient survival and hospital length of stay: a randomised clinical trial. [PDF]

, 2017
IntroductionSeveral methods have been developed to electronically monitor patients for severe sepsis, but few provide predictive capabilities to enable early intervention; furthermore, no severe sepsis prediction systems have been previously validated in
Barton, Christopher W, Das, Ritankar, Feldman, Mitchell D, Mataraso, Samson J, Shimabukuro, David W   +4 more
core   +2 more sources

The CEA Second-Look Trial: a randomised controlled trial of carcinoembryonic antigen prompted reoperation for recurrent colorectal cancer [PDF]

, 2014
Objective In patients who have undergone a potentially curative resection of colorectal cancer, does a ‘second-look’ operation to resect recurrence, prompted by monthly monitoring of carcinoembryonic antigen, confer a survival benefit?Design A randomised
Bacon, Cochrane, Doshi, Ekman, Ellis, Embun, Fiorentino, Fiorentino, Fiorentino, Gill, Goldenberg, Grunhagen, Horton, Keep, Kraemer, Lennon, Levesque, Lewis, Loder, Mach, Mackay, Martin, Martin, Meeker, Moertel, Morris, Nicholson, Northover, Polk, Poston, Primrose, Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2, Rosen, Searle, Staab, Treasure, Treasure, Treasure, Treasure, Utley, Wangensteen, Welch   +41 more
core   +1 more source

IJCM_25A: Effect of one-to-one counselling of mothers attending an immunization clinic on breastfeeding among infants- A Randomised Controlled Trial

Indian Journal of Community Medicine
Background: To improve breastfeeding practices, many interventions have been studied at various critical contact points. Our study aimed to improve exclusive breastfeeding by integrating a limited number of counselling sessions with routine immunization ...
Urmimala Maiti, Khan Amir Maroof, S K Bhasin, Dheeraj Shah   +3 more
doaj   +1 more source

A randomised controlled trial of an Intervention to Improve Compliance with the ARRIVE guidelines (IICARus)

Research Integrity and Peer Review, 2019
Background The ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines are widely endorsed but compliance is limited. We sought to determine whether journal-requested completion of an ARRIVE checklist improves full compliance with the ...
Kaitlyn Hair, Malcolm R. Macleod, Emily S. Sena, on behalf of the IICARus Collaboration   +3 more
doaj   +1 more source

Is the randomised controlled trial the best?

South African Journal of Obstetrics and Gynaecology, 2014
Different study formats are preferred for different research objectives. Randomised controlled trials (RCTs) have a greater ability to test efficacy than other methods, but RCTs can have many limitations. These limitations should be explored, assessed and exposed.
openaire   +2 more sources

Recruiting ethnic minority participants to a clinical trial: a qualitative study [PDF]

, 2013
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non ...
Griffiths, C, Grigg, J, Macneill, V, Nwokoro, C, Seale, C   +4 more
core   +3 more sources

Trial of Acute Femoral Fracture Fixation (TrAFFix): study protocol for a randomised controlled feasibility trial

Trials, 2017
Background Distal femoral fractures are a source of considerable morbidity and best treatment is currently uncertain. The Trial of Acute Femoral Fracture Fixation (TrAFFix) is a randomised, parallel-group feasibility study designed to inform the design ...
Xavier L. Griffin, Matthew L. Costa, Juul Achten, Melina Dritsaki, Janis Baird, Nicholas Parsons   +5 more
doaj   +1 more source

A longitudinal assessment of trial protocols approved by research ethics committees: The Adherance to SPIrit REcommendations in the UK (ASPIRE-UK) study

Trials, 2022
Background To assess the quality of reporting of RCT protocols approved by UK research ethics committees before and after the publication of the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) guideline.
Benjamin Speich, Ayodele Odutayo, Nicholas Peckham, Alexander Ooms, Jamie R. Stokes, Ramon Saccilotto, Dmitry Gryaznov, Belinda von Niederhäusern, Bethan Copsey, Douglas G. Altman, Matthias Briel, Sally Hopewell   +11 more
doaj   +1 more source

Undertaking a randomised controlled trial in the police setting : methodological and practical challenges [PDF]

, 2017
BACKGROUND: There has been an increased drive towards Evidence Based Policing in recent years. Unlike in other public sector services, such as health and education, randomised controlled trials in the police setting are relatively rare.
Booth, Alison, Fairhurst, Caroline, Hewitt, Catherine, McDaid, Catriona, Parker, Adwoa, Payne, Rebecca, Reed, Helen, Scantlebury, Arabella, Scott, William J, Torgerson, David   +9 more
core   +2 more sources