Results 41 to 50 of about 184,908 (263)

An exploration of the factors influencing successful implementation, delivery and outcomes in an intensive care sedation study: process evaluation of the A2B RCT

Health Technology Assessment
Background Choice of sedation of critically ill patients is a core element of intensive care practice. The alpha 2 agonists for sedation to produce better outcomes from critical illness (A2B) trial tested the effectiveness of two alpha agonist sedatives ...
Leanne M Aitken, Lydia M Emerson, Kalliopi Kydonaki, Bronagh Blackwood, Ben Creagh-Brown, Nazir Lone, Cathrine McKenzie, Richard Parker, Michael C Reade, Christopher J Weir, Matt P Wise, Timothy S Walsh   +11 more
doaj   +1 more source

Effects of stimulating single acupoint and combination acupoints on diabetic gastroparesis: A randomised controlled trial study

Journal of Traditional and Complementary Medicine
Background and aim: The most effective among the acupoints remains to be determined for treating diabetic gastroparesis (DGP). This study aimed to compare single and combination acupoints for their effectiveness in DGP.
Renming Liu, Min He, Xuewei Zhao, Mengmeng Sun, Jiazhen Cao, Xinyue Wang, Xingbang Wang, Shuming Zhao, Fuchun Wang, Tie Li   +9 more
doaj   +1 more source

An optimised patient information sheet did not significantly increase recruitment or retention in a falls prevention study: an embedded randomised recruitment trial

Trials, 2017
Background Randomised controlled trials are generally regarded as the ‘gold standard’ experimental design to determine the effectiveness of an intervention.
Sarah Cockayne, Caroline Fairhurst, Joy Adamson, Catherine Hewitt, Robin Hull, Kate Hicks, Anne-Maree Keenan, Sarah E. Lamb, Lorraine Green, Caroline McIntosh, Hylton B. Menz, Anthony C. Redmond, Sara Rodgers, David J. Torgerson, Wesley Vernon, Judith Watson, Peter Knapp, Jo Rick, Peter Bower, Sandra Eldridge, Vichithranie W. Madurasinghe, Jonathan Graffy   +21 more
doaj   +1 more source

Investigating strategies to improve AccesS to Kidney transplantation (the ASK trial): a protocol for a feasibility randomised controlled trial with parallel process evaluation

Pilot and Feasibility Studies, 2023
Background The UK’s living-donor kidney transplant (LDKT) activity falls behind that of many other countries internationally, with less than 20% of those eligible receiving a LDKT each year.
Pippa K. Bailey, Fergus J. Caskey, Stephanie MacNeill, Rachel Ashford, Lindsay Pryce, Liise Kayler, Yoav Ben-Shlomo   +6 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Gefitinib and methotrexate to resolve tubal ectopic pregnancy: the GEM3 RCT

Efficacy and Mechanism Evaluation, 2023
Background Tubal ectopic pregnancies can cause significant morbidity or even death. Current treatment is with methotrexate or surgery. However, methotrexate treatment can fail in approximately 30% of women.
Moakes Catherine A, Tong Stephen, Middleton Lee J, Duncan W Colin, Mol Ben W, Whitaker Lucy H R, Jurkovic Davor, Coomarasamy Arri, Nunes Natalie, Holland Tom, Clarke Fiona, Sutherland Lauren C, Doust Ann M, Daniels Jane P, Horne Andrew W   +14 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Randomised controlled trials [PDF]

Postgraduate Medical Journal, 1999
Randomised controlled trials , Alejandro Jadad, pp 128. BMJ Books, 1998. £12.95 (£11.95 to BMA members), paperback. ISBN 0 7279 1208 9. ★★★ The issue of trial design is increasingly recognised as central to the evaluation of the benefit from any healthcare intervention.
openaire   +1 more source

A randomised controlled trial to evaluate and optimize the use of antiplatelet agents in the perioperative management in patients undergoing general and abdominal surgery- the APAP trial (ISRCTN45810007)

BMC Surgery, 2011
Background Due to the increase of cardiovascular diseases acetylsalicylic acid (ASA) has become one of the most frequently prescribed drugs these days.
Rahbari Nuh N, Contin Pietro, Rakow Anastasia, Reissfelder Christoph, Antolovic Dalibor, Büchler Markus W, Weitz Jürgen, Koch Moritz   +7 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source