Results 101 to 110 of about 158,776 (309)

Intervention protocol: OPtimising thERapy to prevent avoidable hospital Admission in the Multi-morbid elderly (OPERAM): a structured medication review with support of a computerised decision support system

BMC Health Services Research, 2020
Background Several approaches to medication optimisation by identifying drug-related problems in older people have been described. Although some interventions have shown reductions in drug-related problems (DRPs), evidence supporting the effectiveness of
Erin K. Crowley, Bastiaan T. G. M. Sallevelt, Corlina J. A. Huibers, Kevin D. Murphy, Marco Spruit, Zhengru Shen, Benoît Boland, Anne Spinewine, Olivia Dalleur, Elisavet Moutzouri, Axel Löwe, Martin Feller, Nathalie Schwab, Luise Adam, Ingeborg Wilting, Wilma Knol, Nicolas Rodondi, Stephen Byrne, Denis O’Mahony   +18 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Effectiveness of an online training course to improve evidence-based leadership practices among unit leaders: study protocol for a cluster randomised two-arm controlled trial (EVILEAD)

Trials
Background A substantial knowledge base exists on how nurse leaders can support clinical staff in implementing evidence-based knowledge into practice. However, fewer studies are available on how leaders themselves learn and use evidence in their daily ...
Maritta Välimäki, Maija Satamo, Min Yang   +2 more
doaj   +1 more source

A comprehensive evaluation of the impact of telemonitoring in patients with long-term conditions and social care needs: protocol for the whole systems demonstrator cluster randomised trial [PDF]

, 2011
Background: It is expected that increased demands on services will result from expanding numbers of older people with long-term conditions and social care needs.
Adam Steventon, Anne Rogers, Caroline Sanders, Catherine Henderson, Helen Doll, James Barlow, Jane Hendy, Martin Bardsley, Martin Cartwright, Martin Knapp, Peter Bower, Raymond Fitzpatrick, Shashivadan P Hirani, Stanton Newman   +13 more
core   +5 more sources

Antenatal peer support workers and initiation of breast feeding: cluster randomised controlled trial [PDF]

BMJ, 2009
To assess the effectiveness of an antenatal service using community based breastfeeding peer support workers on initiation of breast feeding.Cluster randomised controlled trial.Community antenatal clinics in one primary care trust in a multiethnic, deprived population.66 antenatal clinics with 2511 pregnant women: 33 clinics including 1140 women were ...
MacArthur, Christine, Jolly, Kate, Ingram, Lucy Annang, PhD, Freemantle, Nick, Dennis, Cindy-Lee, Hamburger, Ros, Brown, Julia, Chambers, Jackie, Khan, Khalid   +8 more
openaire   +3 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Adolescents' use of purpose built shade in secondary schools: cluster randomised controlled trial [PDF]

BMJ, 2009
To examine whether students use or avoid newly shaded areas created by shade sails installed at schools.Cluster randomised controlled trial with secondary schools as the unit of randomisation.51 secondary schools with limited available shade, in Australia, assessed over two spring and summer terms.Students outside at lunch times.Purpose built shade ...
Dobbinson, Suzanne J., White, Vanessa., Wakefield, Melanie A., Jamsen, Kris M., White, Victoria., Livingston, Patricia M., English, Dallas R., Simpson, Julie A.   +7 more
openaire   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Coverage and beliefs about temephos application for control of dengue vectors and impact of a community-based prevention intervention: secondary analysis from the Camino Verde trial in Mexico

BMC Public Health, 2017
Background Temephos in domestic water containers remains a mainstay of Latin American government programmes for control of Aedes aegypti and associated illnesses, including dengue.
José Legorreta-Soberanis, Sergio Paredes-Solís, Arcadio Morales-Pérez, Elizabeth Nava-Aguilera, Felipé René Serrano de los Santos, Belén Madeline Sánchez-Gervacio, Robert J. Ledogar, Anne Cockcroft, Neil Andersson   +8 more
doaj   +1 more source

Evaluation of a standard provision versus an autonomy promotive exercise referral programme: rationale and study design [PDF]

, 2009
Background The National Institute of Clinical Excellence in the UK has recommended that the effectiveness of ongoing exercise referral schemes to promote physical activity should be examined in research trials.
A Kirk, A Zigmond, AJ Issacs, AL Dunn, Amanda Daley, C Jenkinson, D Markland, DA Lawlor, Department of Health, Diabetes Prevention Program Research Group, Diabetes Prevention Program Research Group, EB Kahn, EC Nelson, EL Deci, EL Deci, Frank F Eves, GC Williams, GC Williams, GC Williams, GC Williams, GC Williams, GC Williams, Geoffrey C Williams, I Thune, IM Lee, JA Jolliffe, JF Salis, JK Edmunds, JK Edmunds, JK Edmunds, JM Jakicic, Joan L Duda, Kate Jolly, L Dugdill, LA Talbot, M Hillsdon, M Vuori, MS Fortier, N Mutrie, N Sjosten, Nanette Mutrie, National Institute for Health & Clinical Excellence, NH Williams, Nikos Ntoumanis, PC Rouse, Peter C Rouse, PM Wilson, PM Wilson, PM Wilson, PR Brandon, R Ryan, Rekha Lodhia, S Michie, S Rollnick, SH Kaplan, SM Eldridge, SP Helmrich, TJ Bostic, US Department of Health & Human Services, WL Haskell   +59 more
core   +6 more sources