Results 71 to 80 of about 158,776 (309)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Do regulatory tools instigate measures to prevent work-related psychosocial and ergonomic risk factors? A process evaluation of a Labour inspection authority trial in the Norwegian home-care services

BMC Research Notes, 2022
Objective There is a research gap regarding the way managers and employee representatives respond to Labour Authority interventions targeting work-related psychosocial and ergonomic risk factors.
Håkon A. Johannessen, Stein Knardahl, Jan S. Emberland, Øivind Skare, Bjørnar Finnanger Garshol   +4 more
doaj   +1 more source

Impact of CONSORT extension for cluster randomised trials on quality of reporting and study methodology : review of random sample of 300 trials, 2000-8 [PDF]

, 2011
Peer reviewedPublisher ...
Bennett, C, Boruch, R F, Brehaut, J C, Dixon, S, Donner, A, Eccles, M P, Grimshaw, J M, Ivers, N M, McRae, A, Skea, Z, Taleban, J, Taljaard, M, Weijer, C, Zwarenstein, M   +13 more
core   +2 more sources

Health insurance and social capital in Ghana: a cluster randomised controlled trial [PDF]

Global Health Research and Policy, 2018
The National Health Insurance Scheme (NHIS) was introduced in Ghana in 2003, enrolment is still far from the desired target of universal coverage. Low community engagement in the design and management of the system was identified as one of the main barriers. The aim of the current study was to explore the role of social capital in NHIS enrolment in two
Christine J. Fenenga, Katalin Buzasi, Daniel K. Arhinful, Stephen K. O. Duku, Alice Ogink, Wouter Poortinga   +5 more
openaire   +5 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Reconciling research and implementation in micro health insurance experiments in India: study protocol for a randomized controlled trial

Trials, 2011
Background Microinsurance or Community-Based Health Insurance is a promising healthcare financing mechanism, which is increasingly applied to aid rural poor persons in low-income countries.
Doyle Conor, Panda Pradeep, Van de Poel Ellen, Radermacher Ralf, Dror David M   +4 more
doaj   +1 more source

Effect of core versus enhanced implementation strategies on adherence to a clinical pathway for managing anxiety and depression in cancer patients in routine care: a cluster randomised controlled trial

Implementation Science, 2023
Background Optimal strategies to facilitate implementation of evidence-based clinical pathways are unclear. We evaluated two implementation strategies (Core versus Enhanced) to facilitate implementation of a clinical pathway for the management of anxiety
Phyllis Butow, Mona M. Faris, Joanne Shaw, Patrick Kelly, Sharon He, Marnie Harris, Jessica Cuddy, Lindy Masya, Liesbeth Geerligs, Brian Kelly, Afaf Girgis, Nicole Rankin, Philip Beale, Thomas F. Hack, Laura Kirsten, Haryana Dhillon, Peter Grimison, Rosalie Viney, Josephine M. Clayton, Timothy Schlub, The ADAPT Program Group, Heather L. Shepherd   +21 more
doaj   +1 more source

Sample size calculations for cluster randomised controlled trials with a fixed number of clusters [PDF]

, 2011
Background\ud Cluster randomised controlled trials (CRCTs) are frequently used in health service evaluation. Assuming an average cluster size, required sample sizes are readily computed for both binary and continuous outcomes, by estimating a design ...
A Donner, A Donner, A Pourshams, AJ Avery, Alan J Girling, Alice J Sitch, C Brown, C MacArthur, C MacArthur, DM Murray, Jennifer Marsh, Karla Hemming, L Guittet, MJ Davies, MK Campbell, MK Campbell, P Armitage, PL Yudkin, Richard J Lilford, RJ Lilford, SJ Edwards, SM Kerry, SM Kerry, Z Feng   +23 more
core   +4 more sources

Universal HIV testing in London tuberculosis clinics: a cluster randomised controlled trial [PDF]

European Respiratory Journal, 2012
We assessed whether implementation of a combination of interventions in London tuberculosis clinics raised the levels of HIV test offers, acceptance and coverage. A stepped-wedge cluster randomised controlled trial was conducted across 24 clinics.
Roy, A, Anaraki, S, Hardelid, P, Catchpole, M, Rodrigues, LC, Lipman, M, Perkins, S, Roche, A, Stagg, HR, Figueroa, J, Abubakar, I   +10 more
openaire   +3 more sources

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source