Results 81 to 90 of about 158,776 (309)

Changing cluster composition in cluster randomised controlled trials: design and analysis considerations [PDF]

Trials, 2014
There are many methodological challenges in the conduct and analysis of cluster randomised controlled trials, but one that has received little attention is that of post-randomisation changes to cluster composition. To illustrate this, we focus on the issue of cluster merging, considering the impact on the design, analysis and interpretation of trial ...
Corrigan, Neil, Bankart, Michael J. G., Gray, Laura J., Smith, Karen L.   +3 more
openaire   +3 more sources

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Feasibility of a cluster randomised trial on the effect of trauma life support training: a pilot study in India

BMJ Open
Objective To assess the feasibility of conducting a cluster randomised controlled trial comparing the effects of Advanced Trauma Life Support (ATLS) and Primary Trauma Care (PTC) with standard care on patient outcomes.Design This was a pilot pragmatic ...
Kapil Dev Soni, Nobhojit Roy, Martin Gerdin Wärnberg, Monty Khajanchi, Anurag Mishra, Catherine Juillard, Li Fellander-Tsai, Johanna Berg, Shamita Chatterjee, Geeta Ghag, Rajdeep Singh, Lovisa Strömmer, Debojit Basak, Tamal Khan, Vipul Versi Nandu   +14 more
doaj   +1 more source

Effectiveness of a multi-level intervention to reduce men’s perpetration of intimate partner violence: a cluster randomised controlled trial

Trials, 2020
Background Men’s perpetration of intimate partner violence (IPV) limits gains in health and wellbeing for populations globally. Largely informal, rapidly expanding peri-urban settlements, with limited basic services such as electricity, have high ...
Nicola J. Christofides, Abigail M. Hatcher, Dumisani Rebombo, Ruari-Santiago McBride, Shehnaz Munshi, Angelica Pino, Nada Abdelatif, Dean Peacock, Jonathan Levin, Rachel K. Jewkes   +9 more
doaj   +1 more source

IMPLEmenting a clinical practice guideline for acute low back pain evidence-based manageMENT in general practice (IMPLEMENT) : cluster randomised controlled trial study protocol [PDF]

, 2008
Background: Evidence generated from reliable research is not frequently implemented into clinical practice. Evidence-based clinical practice guidelines are a potential vehicle to achieve this.
A Donner, AJ Bellg, AJ Engers, Australian Acute Musculoskeletal Pain Guidelines Group (AAMPGG), B McGuirk, BF Walker, BF Walker, BS Frankel, C Bombardier, C Bombardier, D Di Iorio, D Mortimer, Denise A O'Connor, DG Altman, DG Altman, DK Freeborn, Duncan Mortimer, DW King, DW King, EM Hay, FB Hu, G Waddell, GM Fitzmaurice, H Britt, H Schers, J Francis, J Mollison, J Zhang, Jeremy M Grimshaw, Jill Francis, JJ Yallop, JM Grimshaw, JM Neuhaus, JM Schectman, Joanne E McKenzie, M Campbell, M Eccles, M Roland, M Roland, M Von Korff, MK Campbell, MR Robling, N Klar, Neil Spike, NJ Horton, OC Ukoumunne, P Dey, P Little, P Oakeshott, PB Bishop, Peter M Kent, Peter Schattner, PJ Diggle, PM Kent, R Buchbinder, R Buchbinder, R Buchbinder, R Buchbinder, R Grol, Rachelle Buchbinder, S Hakkennes, S Hollis, S Kerry, S Michie, Sally E Green, Simon D French, SJ Pocock, SJ Senn, SR Heritier, Susan Michie, SZ George, T Permutt, TS Carey, V Gonzalez-Urzelai, W Hardeman   +74 more
core   +4 more sources

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

An empowerment programme to improve diet quality during pregnancy – the Power 4 a Healthy Pregnancy cluster randomised controlled trial

BMC Public Health
Background A healthy diet during pregnancy is vital for the well-being of both mothers and babies. However, navigating dietary choices amidst the unique psychological and physiological changes of pregnancy can be challenging.
Renske M. van Lonkhuijzen, Jeanne H. M. de Vries, Elske Brouwer-Brolsma, Susanne Cremers, Janine P. M. Faessen, Edith J. M. Feskens, Annemarie Wagemakers   +6 more
doaj   +1 more source

A cluster randomised trial of a Needs Assessment Tool for adult Cancer patients and their carers (NAT-C) in primary care: A feasibility study.

PLoS ONE, 2021
BackgroundPeople with cancer often have unidentified symptoms and social care needs. The Needs Assessment Tool-Cancer (NAT-C) is a validated, structured method of assessing patient/carer concerns and prompting action, to address unmet need.AimsAssess ...
Joseph Clark, Elvis Amoakwa, Alexandra Wright-Hughes, John Blenkinsopp, David C Currow, David Meads, Amanda Farrin, Victoria Allgar, Una Macleod, Miriam Johnson   +9 more
doaj   +1 more source

A study protocol for a cluster-randomised controlled trial of smartphone-activated first responders with ultraportable defibrillators in out-of-hospital cardiac arrest: The First Responder Shock Trial (FIRST)

Resuscitation Plus, 2023
Objective: To describe the First Responder Shock Trial (FIRST), which aims to determine whether equipping frequently responding, smartphone-activated (GoodSAM) first responders with an ultraportable AED can increase 30-day survival rates in OHCA. Methods:
Verity Todd, Bridget Dicker, Daniel Okyere, Karen Smith, Tony Smith, Graham Howie, Dion Stub, Michael Ray, Ralph Stewart, Tony Scott, Andy Swain, Natalie Heriot, Aroha Brett, Emily Mahony, Ziad Nehme   +14 more
doaj   +1 more source

Ethical issues in implementation research: a discussion of the problems in achieving informed consent [PDF]

, 2008
Background: Improved quality of care is a policy objective of health care systems around the world. Implementation research is the scientific study of methods to promote the systematic uptake of clinical research findings into routine clinical practice ...
A Iversen, A Vahratian, American Statistical Association, B Briesacher, B Woodward, C Junghans, C Verity, Council of the International Organisation of Medical Sciences, D Raffe, H Ward, International Statistical Institute, J Grimshaw, J Tu, Jane L Hutton, Jeremy M Grimshaw, JL Hutton, JL Hutton, L Doyal, M Eccles, M Eccles, M Eccles, M Robling, M Thompson, Martin P Eccles, MP Eccles, MRC ethics series, R Baker, R Foy, R Grol, R Winkelmann, RE Ashcroft, RE Ashcroft, Royal Statistical Society, S Blackstone, S Rogerson, S Woolf, SJL Edwards, T Beauchap, T Walley, World Medical Association Declaration of Helsinki   +39 more
core   +3 more sources