Results 121 to 130 of about 2,076,484 (318)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Performance evaluation of multi-core multi-cluster architecture

open access: yes, 2014
A multi-core cluster is a cluster composed of numbers of nodes where each node has a number of processors, each with more than one core within each single chip. Cluster nodes are connected via an interconnection network.
Walters, Robert John   +4 more
core  

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Financing cluster initiatives

open access: yes
In the last two decades hundreds of cluster initiatives have been launched involving virtually all regions of the world and their number is growing.
Skokan, Karel
core  

A Scenario-classification Hybrid-based Banding Method for Power Transfer Limits of Critical Inter-corridors

open access: yesJournal of Modern Power Systems and Clean Energy
To secure power system operations, practical dispatches in industries place a steady power transfer limit on critical inter-corridors, rather than high-dimensional and strong nonlinear stability constraints.
Lidong Yi   +8 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Sistem Informasi Pemetaan Penghasil Cengkeh dengan Cluster pada Algoritma K-Means

open access: yes, 2018
Produksi cengkeh di kabupaten tolitoli yang di mana terbesar di semua kecematan, sebagai penghasil cengkeh. Peran dinas perkembunan untuk mengelompokkan dan memetakan mana yang menghasilkan produksi cengkeh, masih dalam kategori terbanyak atau pun ...
Zulkarnain, Zahir Zainuddin, Agussalim
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

A Guide to Cluster Munitions

open access: yes, 2016
Since the CCM entered into force in 2010, much expertise has been acquired by States Parties and partner organisations. This expertise addresses challenges in treaty compliance and best practices that have been developed within the sector to support ...
GICHD,, Munitions, Convention on Cluster
core  

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