Results 41 to 50 of about 1,227,249 (237)

Feature learning augmented with sampling and heuristics (FLASH) improves model performance and biomarker identification

npj Systems Biology and Applications
Big biological datasets, such as gene expression profiles, often contain redundant features that degrade model performance and limit generalization across independent datasets with complexities like class imbalance and hidden sub-clusters.
Shivam Kumar, Abhinav Agarwal, Samrat Chatterjee   +2 more
doaj   +1 more source

konnect2prot 2.0: Integrating advanced analytical tools for deeper understanding of protein properties in a functional protein-protein interaction network

Computational and Structural Biotechnology Journal
Proteins work in coordination to catalyze and regulate all biological activities and drive cellular functions. The collective behavior of proteins is studied through protein-protein interaction (PPI) networks, which provide a system-level understanding ...
Shivam Kumar, Abhinav Agarwal, Dipanka Tanu Sarmah, Samrat Chatterjee   +3 more
doaj   +1 more source

Use of Principal Component Analysis and Cluster Analysis for Differentiation of Traditionally-Manufactured Vinegars Based on Phenolic and Volatile Profiles, and Antioxidant Activity

Polish Journal of Food and Nutrition Sciences, 2020
This study aimed to characterize twelve vinegar samples produced by the traditional method with the use of whole fruits and without any preservatives in terms of their physicochemical properties, total phenolic content (TPC), total flavonoid content (TFC)
Ayse Karadag, Fatih Bozkurt, Hatice Bekiroglu, Osman Sagdic   +3 more
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Exploring the determinants of energy poverty in Indonesia’s households: empirical evidence from the 2015–2019 SUSENAS

Humanities & Social Sciences Communications
This study explores the determinants of household-level energy poverty in Indonesia by using highly granular, household-level socioeconomic data on Indonesia from the 2015–2019 National Socioeconomic Survey (SUSENAS).
Novani Karina Saputri, Lourentius Dimas Setyonugroho, Djoni Hartono   +2 more
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Should Developed Regions Bear More Responsibility in Addressing Environmental Issues? Insights from Indonesia's Unequal Regional Development

Energy Nexus
Addressing environmental issues is inherently complex due to the fundamental question of who bears responsibility. While more prominent at the global level, this issue is also pertinent on a subnational level, such as in Indonesia, where significant ...
Fikri Muhammad, Djoni Hartono, Sasmita Hastri Hastuti, Arianto A. Patunru, Audhi Ahmad Balya   +4 more
doaj   +1 more source

Versatile Mitogenic and Differentiation‐Inducible Layer Formation by Underwater Adhesive Polypeptides

Advanced Science, 2021
Artificial materials have no biological functions, but they are important for medical devices such as artificial organs and matrices for regenerative medicine.
Seiichi Tada, Xueli Ren, Hongli Mao, Yun Heo, Shin‐Hye Park, Takashi Isoshima, Liping Zhu, Xiaoyue Zhou, Reiko Ito, Shino Kurata, Megumi Osaki, Eiry Kobatake, Yoshihiro Ito   +12 more
doaj   +1 more source