Results 81 to 90 of about 27,265,132 (376)

Cluster morphology analysis [PDF]

Spatial and Spatio-temporal Epidemiology, 2009
Most disease clustering methods assume specific shapes and do not evaluate statistical power using the applicable geography, at-risk population, and covariates. Cluster Morphology Analysis (CMA) conducts power analyses of alternative techniques assuming clusters of different relative risks and shapes.
openaire   +2 more sources

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Should Developed Regions Bear More Responsibility in Addressing Environmental Issues? Insights from Indonesia's Unequal Regional Development

Energy Nexus
Addressing environmental issues is inherently complex due to the fundamental question of who bears responsibility. While more prominent at the global level, this issue is also pertinent on a subnational level, such as in Indonesia, where significant ...
Fikri Muhammad, Djoni Hartono, Sasmita Hastri Hastuti, Arianto A. Patunru, Audhi Ahmad Balya   +4 more
doaj   +1 more source

Versatile Mitogenic and Differentiation‐Inducible Layer Formation by Underwater Adhesive Polypeptides

Advanced Science, 2021
Artificial materials have no biological functions, but they are important for medical devices such as artificial organs and matrices for regenerative medicine.
Seiichi Tada, Xueli Ren, Hongli Mao, Yun Heo, Shin‐Hye Park, Takashi Isoshima, Liping Zhu, Xiaoyue Zhou, Reiko Ito, Shino Kurata, Megumi Osaki, Eiry Kobatake, Yoshihiro Ito   +12 more
doaj   +1 more source

The Distance to NGC 2264 [PDF]

, 2009
We determine the distance to the open cluster NGC 2264 using a statistical analysis of cluster member inclinations. We derive distance-dependent values of sin i (where i is the inclination angle) for 97 stars in NGC 2264 from the rotation periods ...
Andrew H. Szentgyorgyi, August A. Muench, Baraffe, Bouvier, Dahm, Delfosse, Duquennoy, Eric J. Baxter, Flaccomio, Fűrész, Gábor Fűrész, Hartmann, Hendry, Johns-Krull, Kevin R. Covey, Lada, Leggett, Luisa Rebull, Makidon, Neri, O'Dell, Park, Preibisch, Rebull, Rebull, Texeira, Texeira, Walker, White   +28 more
core   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Cluster Analysis [PDF]

, 2009
Dalam analisis cluster mempelajari hubungan interdependensi antara seluruh set variabel perlu diteliti. Tujuan utama analisis cluster adalah mengekelompokkan obyek (elemen) seperti orang, produk (barang), toko, perusahaan ke dalam kelompok-kelompok yang ...
Hery Tri, Sutanto
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source