Results 101 to 110 of about 3,326,211 (292)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Energy Poverty and Subjective Wellbeing: Empirical Analysis in Indonesia

Jurnal Ekonomi Pembangunan
As stated in the Sustainable Development Goals, energy poverty is a severe problem that is a priority for the United Nations to eradicate. In general, the study on energy poverty is concerned with objective indicators. More study still needs to evaluate
Zetara Zetara, Djoni Hartono
doaj   +1 more source

Suzaku Observation of the Ophiuchus Galaxy Cluster: One of the Hottest Cool Core Clusters

, 2008
We present the analysis of a Suzaku observation of the Ophiuchus galaxy cluster. We confirmed that the cluster has a cool core. While the temperature of the intracluster medium (ICM) decreases toward the center, the metal abundance increases.
Fujita, Yutaka, Hayashida, Kiyoshi, Inoue, Susumu, Matsumoto, Hironori, Nagai, Masaaki, Okabe, Nobuhiro, Reiprich, Thomas. H., Sarazin, Craig L., Takizawa, Motokazu   +8 more
core   +2 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Polymorph selection towards photocatalytic gaseous CO2 hydrogenation

Nature Communications, 2019
Titanium dioxide is the only known material that can enable gas-phase CO2 photocatalysis in its anatase and rutile polymorphic forms. Materials engineering of polymorphism provides a useful strategy for optimizing the performance metrics of a ...
Tingjiang Yan, Lu Wang, Yan Liang, Meysam Makaremi, Thomas E. Wood, Ying Dai, Baibiao Huang, Feysal M. Ali, Yuchan Dong, Geoffrey A. Ozin   +9 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Multiple merging in the Abell cluster 1367

, 2004
We present a dynamical analysis of the central ~1.3 square degrees of the cluster of galaxies Abell 1367, based on 273 redshift measurements (of which 119 are news).
Boselli, A., Carrasco, L., Cortese, L., Gavazzi, G., Iglesias-Paramo, J.   +4 more
core   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

A Multifunctional Therapeutic Strategy Using P7C3 as A Countermeasure Against Bone Loss and Fragility in An Ovariectomized Rat Model of Postmenopausal Osteoporosis

Advanced Science
By 2060, an estimated one in four Americans will be elderly. Consequently, the prevalence of osteoporosis and fragility fractures will also increase. Presently, no available intervention definitively prevents or manages osteoporosis.
Fei Wei, Megan Hughes, Mahmoud Omer, Christopher Ngo, Abinaya Sindu Pugazhendhi, Elayaraja Kolanthai, Matthew Aceto, Yasmine Ghattas, Mehdi Razavi, Thomas J Kean, Sudipta Seal, Melanie Coathup   +11 more
doaj   +1 more source