Results 111 to 120 of about 1,519,867 (319)

Recommendations for updating CDC/CSTE cancer cluster investigation guidelines [PDF]

open access: yes
In 2021, ASTHO convened a workgroup of public health experts to assess the 2013 CDC/CSTE Cancer Cluster Investigation Guidelines for updates and revisions.

core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

HIV molecular cluster detection and response [PDF]

open access: yes
CDC uses cutting-edge technology to detect and respond to clusters of HIV transmission in the United States. This is a critical step that will bring the nation closer to the goal of no new HIV infections.cdc-hiv-factsheet-molecular-cluster-identification.

core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Business Ethics in Transition Countries – Cluster Analysis of Behavior and Attitudes [PDF]

open access: yes
The aim of this article is to obtain a better understanding of people’s attitudes toward ethical issues. We explored four ethics issues: (1) attitude on ethical issues in general, (2) information manipulation, (3) environmental issues, and (4) law issues.
Marina Dabić   +2 more
core  

Scientists and information: I. Using cluster analysis to identify information style

open access: yes, 1991
Semi‐structured, in‐depth interviews were used to explore the influence of personality, discipline and organisational structure on the information behaviour of biochemists, entomologists and statisticians working at an agricultural research station (n ...
Palmer, J. M. P.
core   +1 more source

Does education affect energy behavior? Investigating the influence of educational attainment in Indonesia

open access: yesSocial Sciences and Humanities Open
This study investigates the causal relationship between educational attainment and various energy behaviors, including clean cooking fuel use, energy conservation practices, and energy-efficient technology adoption.
Lilia Endriana   +3 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

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