Results 101 to 110 of about 1,520,463 (346)

Macrolide Resistance in MORDOR I: A Cluster-Randomized Trial in Niger

New England Journal of Medicine, 2019
Macrolide Antimicrobial Resistance in MORDOR I In MORDOR I, azithromycin decreased mortality in children in Niger.
T. Doan, A. Arzika, Armin Hinterwirth, R. Maliki, Lina Zhong, S. Cummings, Samarpita Sarkar, Cindi Chen, T. Porco, J. Keenan, T. Lietman   +10 more
semanticscholar   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Learn Kind: a cluster randomized controlled trial

Discover Education
Can you teach schoolchildren to be kinder? We conducted a randomized controlled trial of Learn Kind—a kindness-based SEL curriculum for grades K-8, designed by kindness.org.
Mehmet Necip Tunç, Chloe San Miguel, Megan Peterson, Rebecca Reed, Jaclyn Lindsey, Oliver Scott Curry   +5 more
doaj   +1 more source

Challenges of cluster randomized trials

Journal of Comparative Effectiveness Research, 2014
Cluster randomized trials are trials that randomize clusters of people, rather than individuals. They are becoming increasingly common. A number of innovations have been developed recently, particularly in the calculation of the required size of a cluster trial, the handling of missing data, designs to minimize recruitment bias, the ethics of cluster ...
openaire   +2 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Robotic versus electromagnetic bronchoscopy for pulmonary leslon assessment using integrated intraprocedural imaging: Study protocol for the reliant 2 trial.

PLoS ONE
BackgroundRobotic assisted bronchoscopy (RAB) and electromagnetic navigational bronchoscopy (ENB) are two approaches to biopsy peripheral pulmonary lesions (PPLs). A recently completed cluster randomized controlled trial, RELIANT (NCT05705544), showed no
Rafael Paez, Ankush P Ratwani, Jennifer D Duke, Greta Bridwell, Kaele Leonard, James M Katsis, Edward M Pickering, Jeffrey Thiboutot, Heidi Chen, Sheau-Chiann Chen, Samira Shojaee, Lonny Yarmus, Robert J Lentz, Fabien Maldonado, Interventional Pulmonary Outcomes Group   +14 more
doaj   +1 more source

Choosing an imbalance metric for covariate-constrained randomization in multiple-arm cluster-randomized trials

Trials, 2019
Background In cluster-randomized controlled trials (C-RCTs), covariate-constrained randomization (CCR) methods efficiently control imbalance in multiple baseline cluster-level variables, but the choice of imbalance metric to define the subset of ...
Jody D. Ciolino, Alicia Diebold, Jessica K. Jensen, Gerald W. Rouleau, Kimberly K. Koloms, Darius Tandon   +5 more
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

An integrated general practice and pharmacy-based intervention to promote the use of appropriate preventive medications among individuals at high cardiovascular disease risk: protocol for a cluster randomized controlled trial [PDF]

, 2016
Background: Cardiovascular diseases (CVD) are responsible for significant morbidity, premature mortality, and economic burden. Despite established evidence that supports the use of preventive medications among patients at high CVD risk, treatment gaps ...
Adina Hayek, Anthony Rodgers, Antithrombotic Trialists’ Collaboration, Antithrombotic Trialists’ Collaboration, Anushka Patel, B Mitchell, B Patel, Baldeep Kaur, Bandana Saini, BL Carter, BL Svarstad, BL Svarstad, Blood Pressure Lowering Treatment Trialists' Collaboration, C Armour, C Baigent, Carol Armour, Charlotte Hespe, Christopher Reid, D Peiris, D Peiris, D Peiris, David Peiris, DE Morisky, DE Morisky, DM Wentzlaff, DP Peiris, E Hatah, EL Heeley, Fred Hersch, GF Moore, Ines Krass, JK Lee, KL Margolis, Louise Shiel, M Krousel-Wood, MP Morgado, N Houston Miller, P Ho, R Webster, RB Haynes, RJ Webster, Rohina Joshi, Ruth Webster, S Jan, S Michie, Serigne Lo, Stephen Jan, Tim Usherwood, Tracey-Lea Laba, WK Kellogg Foundation, World Health Organisation   +50 more
core   +4 more sources

Salt substitution and salt-supply restriction for lowering blood pressure in elderly care facilities: a cluster-randomized trial

Nature Medicine, 2023
Yifang Yuan, A. Jin, B. Neal, Xiangxian Feng, Qianku Qiao, Hongxia Wang, Ruijuan Zhang, Jiayu Li, Peifen Duan, La’e Cao, Hui Zhang, Senke Hu, Huijuan Li, P. Gao, Gaoqiang Xie, Jianhui Yuan, Lili Cheng, Sujuan Wang, Haijun Zhang, W. Niu, H. Fang, Minghui Zhao, R. Gao, Junshi Chen, P. Elliott, D. Labarthe, Yangfeng Wu   +26 more
semanticscholar   +1 more source