Results 131 to 140 of about 1,520,463 (346)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Implementation strategies to integrate HIV and hypertension care in Kampala and Wakiso districts, Uganda: study protocol for a stepped wedge cluster randomized trial (PULESA-Uganda)

BMC Health Services Research
Background Hypertension (HTN) is the leading cause of cardiovascular morbidity and mortality among people living with HIV (PLWH) in Africa, yet integration of hypertension treatment in HIV clinics is sub-optimal.
Chris T. Longenecker, John Baptist Kiggundu, Florence Ayebare, Martin Muddu, James Kayima, Gerald Mutungi, Isaac Ssinabulya, Jeremy I. Schwartz, Donna Spiegelman, Guangyu Tong, Rachel Nugent, Angela Aifah, Faith Kagoya, Drew B. Cameron, Brian Hutchinson, Moses R. Kamya, Anne R. Katahoire, Fred C. Semitala   +17 more
doaj   +1 more source

Dual-mobIlity verSus conventional Total hip arthroplasty In femoral Neck fractures, a registry-nested, open-label, Cluster-randomized crossover Trial (DISTINCT): statistical analysis plan

Bone & Joint Open
Aims: A statistical analysis plan for analysis of DISTINCT (Dual-mobIlity verSus conventional Total hip arthroplasty In femoral Neck fractures, a registry-nested, open-label, Cluster-randomized crossover Trial) is outlined to aid transparency in ...
The DISTINCT Study Group
doaj   +1 more source

Stepping Stones and Creating Futures Intervention to Prevent Intimate Partner Violence Among Young People: Cluster Randomized Controlled Trial.

Journal of Adolescent Health, 2019
PURPOSE Young people, not in formal employment or education, face exceedingly high levels of intimate partner violence (IPV). We evaluated whether Stepping Stones and Creating Futures, compared with a wait-list control, can reduce IPV and strengthen ...
A. Gibbs, L. Washington, Nada Abdelatif, E. Chirwa, S. Willan, N. Shai, Y. Sikweyiya, S. Mkhwanazi, N. Ntini, R. Jewkes   +9 more
semanticscholar   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Determining the impact of a new physiotherapist-led primary care model for back pain: protocol for a pilot cluster randomized controlled trial

Trials, 2017
Background Back pain is a leading contributor to disability, healthcare costs, and lost work. Family physicians are the most common first point of contact in the healthcare system for people with back pain, but physiotherapists (PTs) may be able to ...
Jordan Miller, David Barber, Catherine Donnelly, Simon French, Michael Green, Jonathan Hill, Joy MacDermid, Jacquelyn Marsh, Kathleen Norman, Julie Richardson, Monica Taljaard, Timothy Wideman, Lynn Cooper, Colleen McPhee   +13 more
doaj   +1 more source

Preventive measures in infancy to reduce under-five mortality: a case-control study in The Gambia.

, 2009
OBJECTIVE: To investigate the relationship between child mortality and common preventive interventions: vaccination, trained birthing attendants, tetanus toxoid during pregnancy, breastfeeding and vitamin A supplementation. METHODS: Case-control study in
Adegbola, Richard A, Dockerty, John D, Herbison, Peter, Hill, Philip C, Howie, Stephen RC, Jasseh, Momodou, Jeffries, David J, Mulholland, Kim, Rutherford, Merrin E   +8 more
core   +1 more source

Incidence and mortality of nasopharyngeal carcinoma: interim analysis of a cluster randomized controlled screening trial (PRO-NPC-001) in southern China.

Annals of Oncology, 2019
BACKGROUND Previous mass screening studies have shown that IgA antibodies against Epstein-Barr Virus (EBV) can facilitate early detection of Nasopharyngeal carcinoma (NPC), but the impact of EBV-antibody screening for NPC-specific mortality remains ...
M. Ji, Wei Sheng, W. Cheng, M. Ng, B. Wu, X. Yu, K. Wei, F. Li, S. Lian, Ping Wang, W. Quan, L. Deng, Xuri Li, X. D. Liu, Y. Xie, S. J. Huang, Shengxiang Ge, S. Huang, X. Liang, S. He, H. Huang, S. Xia, P. Ng, Honglin Chen, S. Xie, Qiang Liu, M. Hong, Jun Ma, Yujie Yuan, Ningshao Xia, Jun Zhang, S. Cao   +31 more
semanticscholar   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Cost-effectiveness analysis of 3-D computerized tomography colonography versus optical colonoscopy for imaging symptomatic gastroenterology patients.

, 2013
BACKGROUND: When symptomatic gastroenterology patients have an indication for colonic imaging, clinicians have a choice between optical colonoscopy (OC) and computerized tomography colonography with three-dimensional reconstruction (3-D CTC).
A Briggs, A Graser, A Sweet, AI Neugut, B Bressler, B Bressler, B Hofstad, B Hofstad, BCSP Nhs, BP Mulhall, C Dukes, C Hassan, C Hassan, CD Johnson, D Burling, D Lee, DA Johnson, Department of Health and Human Services, DG Fryback, DH Kim, DJ Brenner, DK Rex, DK Rex, DK Rex, EC Obusez, F Loeve, HE Knoernschild, J Dowie, JA DiSario, James Bell, JJ Gonvers, L Ries, LM Almond, M Bose, M Chaparro, M Drummond, M McHugh, Manuel Gomes, ME Zalis, NICE, NICE, NICE, NM Gatto, Owen Epstein, P Consolo, P Tappenden, P Wylie, PB Cotton, Peter Wylie, PJ Pickhardt, PJ Pickhardt, PJ Pickhardt, PJ Pickhardt, PJ Pickhardt, PJ Pickhardt, PJ Pickhardt, RE Gelder Van, RE Schoen, RM Ness, Robert W. Aldridge, S Halligan, S Halligan, S Vijan, SJ Winawer, T Vanni, TR Levin, WS Atkin, WS Atkin   +67 more
core   +1 more source