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Balance in cluster randomized trials
Statistics in Medicine, 2001This paper explores the role of balancing covariates between treatment groups in the design of cluster randomized trials. General expressions are obtained for two criteria to evaluate designs for parallel group studies with two treatments. The first is the variance of the estimated treatment effect and the second is the extent to which the estimated ...
G M, Raab, I, Butcher
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Randomization inference for balanced cluster-randomized trials
Clinical Trials, 2005This paper discusses the choice of randomization tests for inferences from cluster-randomized trials that have been designed to ensure a balanced allocation of clusters to treatments. Methods for covariate-adjusted randomization tests are reviewed and their application to balanced cluster-randomized trials discussed. Two cluster-randomized trials with
Gillian M, Raab, Isabella, Butcher
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The Cluster Randomized Trial Study Design
AJN, American Journal of Nursing, 2023Editor's note: This is the 17th article in a series on clinical research by nurses. The series is designed to be used as a resource for nurses to understand the concepts and principles essential to research. Each column will present the concepts that underpin evidence-based practice—from research design to data interpretation.
Bernadette, Capili, Joyce K, Anastasi
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Intra‐cluster correlation selection for cluster randomized trials
Statistics in Medicine, 2016In this paper, we give focus to cluster randomized trials, also known as group randomized trials, which randomize clusters, or groups, of subjects to different trial arms, such as intervention or control. Outcomes from subjects within the same cluster tend to exhibit an exchangeable correlation measured by the intra‐cluster correlation coefficient (ICC)
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Cluster Randomization Trials: A Simulation Study
Biometrical Journal, 2002zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Song, James X., Ahn, Chul
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Cluster randomized trials for HIV prevention
Current Opinion in HIV and AIDS, 2006This paper reviews cluster randomized trials for HIV prevention, focusing on the unique aspects of such trials and describes key cluster randomized trials for HIV prevention from the past decade. Relevant methodological issues are also reviewed.Three cluster randomized trials evaluating sexually transmitted infection control as an HIV prevention tool ...
James P, Hughes, Michal, Kulich
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Cluster-randomized trials: A closer look
Clinical Trials, 2016Background: The cluster-randomized trial is the methodology of choice for evaluating interventions administered at the group level such as public health and healthcare quality improvement interventions. Because of unique features of this design, it can be difficult to apply standard research ethics guidelines to cluster-randomized trials.
Andrew D, McRae +2 more
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Cluster Randomized Trials:Another Look
Hastings Center Report, 2013The type of research known as cluster randomized trials raises ethical questions not readily answered within the standard understanding of research ethics. What distinguishes a CRT is that it randomizes at the level of social groups rather than at the level of individual research participants: in a CRT, the regimen under study might be assigned to a ...
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Cluster Randomized Clinical Trials
2017This chapter discusses the design and analysis of cluster randomized clinical trials (CRCTs). These trials are useful when the intervention is most appropriately applied at a group level (e.g., provider, clinic, hospital). Since patients within a provider, clinic, or hospital are more likely to be similar than patients from another provider, clinic, or
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