Results 41 to 50 of about 333,099 (299)

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Selection bias and subject refusal in a cluster-randomized controlled trial

BMC Medical Research Methodology, 2017
Background Selection bias and non-participation bias are major methodological concerns which impact external validity. Cluster-randomized controlled trials are especially prone to selection bias as it is impractical to blind clusters to their allocation ...
Rochelle Yang, Barry L. Carter, Tyler H. Gums, Brian M. Gryzlak, Yinghui Xu, Barcey T. Levy   +5 more
doaj   +1 more source

Filipino Multicomponent Intervention to Maintain Cognitive Performance in High-Risk Population (FINOMAIN): Study Protocol for a Cluster Randomized Controlled Trial

Frontiers in Neurology, 2021
Background: More than half of the people with dementia live in lower-middle income countries (LMIC), yet we lack research and evidence-based knowledge to guide health promotion and prevention strategies for cognitive decline.
Jacqueline Dominguez, Jacqueline Dominguez, Ma. Fe de Guzman, S. H. Annabel Chen, Mary Sano, Gunhild Waldemar, Gunhild Waldemar, Thien Kieu Thi Phung   +7 more
doaj   +1 more source

Impact of early initiation versus national standard of care of antiretroviral therapy in Swaziland's public sector health system : study protocol for a stepped-wedge randomized trial [PDF]

, 2017
Background: There is robust clinical evidence to support offering early access to antiretroviral treatment (ART) to all HIV-positive individuals, irrespective of disease stage, to both improve patient health outcomes and reduce HIV incidence. However, as
Barnighausen, Till, Delva, Wim, Fleming, Yvette, Khumalo, Gavin, Lejeune, Charlotte L, Mazibuko, Sikhathele, Mlambo, Charmaine Khudzie, Okello, Velephi, Reis, Ria, Spiegelman, Donna, Walsh, Fiona J, Zwane, Mandisa   +11 more
core   +5 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

BETTER HEALTH: Durham -- protocol for a cluster randomized trial of BETTER in community and public health settings

BMC Public Health, 2017
Background The Building on Existing Tools to Improve Chronic Disease Prevention and Screening (BETTER) cluster randomized trial in primary care settings demonstrated a 30% improvement in adherence to evidence-based Chronic Disease Prevention and ...
Lawrence Paszat, Rinku Sutradhar, Mary Ann O’Brien, Aisha Lofters, Andrew Pinto, Peter Selby, Nancy Baxter, Peter D. Donnelly, Regina Elliott, Richard H. Glazier, Robert Kyle, Donna Manca, Mary-Anne Pietrusiak, Linda Rabeneck, Nicolette Sopcak, Jill Tinmouth, Becky Wall, Eva Grunfeld   +17 more
doaj   +1 more source

Cluster randomised trials in the medical literature: two bibliometric surveys [PDF]

, 2004
Background: Several reviews of published cluster randomised trials have reported that about half did not take clustering into account in the analysis, which was thus incorrect and potentially misleading.
A Donner, A Donner, A Donner, C Emslie, CM Wright, CR Elley, D Nutbeam, DG Altman, DG Altman, DM Murray, E Rink, G Meyer, J Cornfield, J Martin Bland, JCFM Wetsteyn, JM Bland, JM Bland, JM Simpson, MAH Russell, MJ Gardner, MJ Gardner, MK Campbell, P Isaakidis, S Puffer, SM Eldridge, SM Kerry, SM Kerry, SM Kerry, SP Varnell   +28 more
core   +4 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Implementation research on the intervention mode of “Comorbidity—Co-causes—Joint-prevention” comprehensive demonstration district of depression and obesity among children and adolescents in Beijing: study protocol

BMC Public Health
Background Depression and obesity among adolescents have become major public health problems. They have common biological mechanisms and overlapping risk factors, such as lack of exercise, poor diet, and sleep disorders.
Xinxin Wang, PingPing Gui, Junkang Lin, YanJie Zhao, Xiaorui Zhang, Yi Song, Linghui Meng   +6 more
doaj   +1 more source

Oxygen treatment for cluster headache attacks at different flow rates: a double-blind, randomized, crossover study

The Journal of Headache and Pain, 2018
Background Cluster headache attacks can, in many patients, be successfully treated with oxygen via a non-rebreather mask. In previous studies oxygen at flow rates of both 7 L/min and 12 L/min was shown to be effective.
Thijs H. T. Dirkx, Danielle Y. P. Haane, Peter J. Koehler   +2 more
doaj   +1 more source