Results 71 to 80 of about 1,520,463 (346)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The Design and Sample Size Requirement for a Cluster Randomized Non-Inferiority Trial with Two Binary Co-Primary Outcomes. [PDF]

, 2008
This paper will discuss the design and sample size requirement for a cluster randomized non-inferiority trial with two binary co-primary outcomes. A hypothetical study (the EXAMPLE Trial) will be considered.
McCarthy, William F.
core   +1 more source

Cluster randomised trials in the medical literature: two bibliometric surveys [PDF]

, 2004
Background: Several reviews of published cluster randomised trials have reported that about half did not take clustering into account in the analysis, which was thus incorrect and potentially misleading.
A Donner, A Donner, A Donner, C Emslie, CM Wright, CR Elley, D Nutbeam, DG Altman, DG Altman, DM Murray, E Rink, G Meyer, J Cornfield, J Martin Bland, JCFM Wetsteyn, JM Bland, JM Bland, JM Simpson, MAH Russell, MJ Gardner, MJ Gardner, MK Campbell, P Isaakidis, S Puffer, SM Eldridge, SM Kerry, SM Kerry, SM Kerry, SP Varnell   +28 more
core   +4 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

A home‐based, primary‐care model for epilepsy care in India: Basis and design

Epilepsia Open, 2019
Summary Objectives A cluster‐randomized trial of home‐based care using primary‐care resources for people with epilepsy has been set up to optimize epilepsy care in resource‐limited communities in low‐ and middle‐income countries.
Gagandeep Singh, Suman Sharma, Rajnder K. Bansal, Raj K. Setia, Sarit Sharma, Namita Bansal, Anuraag Chowdhury, Jatinder S. Goraya, Susmita Chatterjee, Sukhpreet Kaur, Manpreet Kaur, Shivani Kalra, Josemir W. Sander   +12 more
doaj   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Evaluation of Typhoid Conjugate Vaccine Effectiveness in Ghana (TyVEGHA) Using a Cluster-Randomized Controlled Phase IV Trial: Trial Design and Population Baseline Characteristics

Vaccines, 2021
Typhoid fever remains a significant health problem in sub-Saharan Africa, with incidence rates of >100 cases per 100,000 person-years of observation. Despite the prequalification of safe and effective typhoid conjugate vaccines (TCV), some uncertainties ...
Andrea Haekyung Haselbeck, Birkneh Tilahun Tadesse, Juyeon Park, Malick M. Gibani, Ligia María Cruz Espinoza, Ariane Abreu, Craig Van Rensburg, Michael Owusu-Ansah, Sampson Twuamsi-Ankrah, Michael Owusu, Isaac Aguna, Valentina Picot, Hyonjin Jeon, Ellen Higginson, Sunju Park, Zenaida R. Mojares, Justin Im, Megan E. Carey, Farhana Khanam, Susan Tonks, Gordon Dougan, Deokryun Kim, Jonathan Sugimoto, Vittal Mogasale, Kathleen M. Neuzil, Firdausi Qadri, Yaw Adu-Sarkodie, Ellis Owusu-Dabo, John Clemens, Florian Marks   +29 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Influenza vaccination in patients with acute heart failure (PANDA II): study protocol for a hospital-based, parallel-group, cluster randomized controlled trial in China

Trials
Background Influenza vaccination confers broad benefits in the elderly and certain high-risk populations, but its effectiveness in patients with acute heart failure (HF) is uncertain. Rates of influenza vaccination are low in China due to poor awareness,
Yiqun Zhang, Rong Liu, Yangyang Zhao, Zhiyan Wang, Chi Wang, Qiang Li, Dorothy Han, Craig S. Anderson, Xin Du, Jianzeng Dong   +9 more
doaj   +1 more source

GeriMedRisk, a telemedicine geriatric pharmacology consultation service to address adverse drug events in long-term care: a stepped-wedge cluster randomized feasibility trial protocol (ISRCTN17219647)

Pilot and Feasibility Studies, 2018
Background Multimorbidity, polypharmacy, and older age predispose seniors to adverse drug events (ADE). Seniors with an ADE experience greater morbidity, mortality, and health care utilization compared to their younger counterparts.
Joanne Man-Wai Ho, Jennifer Tung, Janine Maitland, Derelie Mangin, Lehana Thabane, J. Michael Pavlin, Jeffrey Alfonsi, Anne Holbrook, Sharon Straus, Sophiya Benjamin   +9 more
doaj   +1 more source