Results 71 to 80 of about 334,888 (299)

Intracluster correlation coefficients in the Greater Mekong Subregion for sample size calculations of cluster randomized malaria trials

Malaria Journal, 2019
Background Sample size calculations for cluster randomized trials are a recognized methodological challenge for malaria research in pre-elimination settings.
Pimnara Peerawaranun, Jordi Landier, Francois H. Nosten, Thuy-Nhien Nguyen, Tran Tinh Hien, Rupam Tripura, Thomas J. Peto, Koukeo Phommasone, Mayfong Mayxay, Nicholas P. J. Day, Arjen Dondorp, Nick White, Lorenz von Seidlein, Mavuto Mukaka   +13 more
doaj   +1 more source

Community Case Management of Fever Due to Malaria and Pneumonia in Children Under Five in Zambia: A Cluster Randomized Controlled Trial [PDF]

, 2010
In a cluster randomized trial, Kojo Yeboah-Antwi and colleagues find that integrated management of malaria and pneumonia in children under five by community health workers is both feasible and effective. BACKGROUND.
Hamainza, Busiku, Hamer, Davidson H., Kalesha, Penelope, Kamholz, Karen, Macleod, William B., Mazimba, Arthur, Pilingana, Portipher, Sabin, Lora, Seidenberg, Phil, Semrau, Katherine, Siazeele, Kazungu, Thea, Donald M., Yeboah-Antwi, Kojo   +12 more
core   +5 more sources

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Effectiveness of social marketing strategies to reduce youth obesity in European school-based interventions : a systematic review and meta-analysis [PDF]

, 2016
Peer reviewedPublisher ...
Aceves Martins, Magaly, Giralt, Montse, Llauradó, Elisabet, Moreno-Garcia, Carlos Francisco, Solà, Rosa, Tarro, Lucia, Trujillo Escobar, Tamy Goretty   +6 more
core   +5 more sources

Informed Consent and Cluster-Randomized Trials

American Journal of Public Health, 2012
We argue that cluster-randomized trials are an important methodology, essential to the evaluation of many public health interventions. However, in the case of at least some cluster-randomized trials, it is not possible, or is incompatible with the aims of the study, to obtain individual informed consent.
Julius, Sim, Angus, Dawson
openaire   +3 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Maximin Optimal Designs for Cluster Randomized Trials [PDF]

Biometrics, 2017
SummaryWe consider design issues for cluster randomized trials (CRTs) with a binary outcome where both unit costs and intraclass correlation coefficients (ICCs) in the two arms may be unequal. We first propose a design that maximizes cost efficiency (CE), defined as the ratio of the precision of the efficacy measure to the study cost.
Wu, Sheng, Wong, Weng Kee, Crespi, Catherine M   +2 more
openaire   +4 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Learn Kind: a cluster randomized controlled trial

Discover Education
Can you teach schoolchildren to be kinder? We conducted a randomized controlled trial of Learn Kind—a kindness-based SEL curriculum for grades K-8, designed by kindness.org.
Mehmet Necip Tunç, Chloe San Miguel, Megan Peterson, Rebecca Reed, Jaclyn Lindsey, Oliver Scott Curry   +5 more
doaj   +1 more source

Step-wedge cluster-randomised community-based trials: An application to the study of the impact of community health insurance [PDF]

, 2008
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work ...
Becher, H, Bridger, JM, De Allegri, M, Dong, H, Gbangou, A, Kouyaté, B, Kynast-Wolf, G, Mansmann, U, Pokhrel, S, Sanon, M, Sauerborn, R   +10 more
core   +3 more sources