Results 81 to 90 of about 334,888 (299)

Challenges of cluster randomized trials

Journal of Comparative Effectiveness Research, 2014
Cluster randomized trials are trials that randomize clusters of people, rather than individuals. They are becoming increasingly common. A number of innovations have been developed recently, particularly in the calculation of the required size of a cluster trial, the handling of missing data, designs to minimize recruitment bias, the ethics of cluster ...
openaire   +2 more sources

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Robotic versus electromagnetic bronchoscopy for pulmonary leslon assessment using integrated intraprocedural imaging: Study protocol for the reliant 2 trial.

PLoS ONE
BackgroundRobotic assisted bronchoscopy (RAB) and electromagnetic navigational bronchoscopy (ENB) are two approaches to biopsy peripheral pulmonary lesions (PPLs). A recently completed cluster randomized controlled trial, RELIANT (NCT05705544), showed no
Rafael Paez, Ankush P Ratwani, Jennifer D Duke, Greta Bridwell, Kaele Leonard, James M Katsis, Edward M Pickering, Jeffrey Thiboutot, Heidi Chen, Sheau-Chiann Chen, Samira Shojaee, Lonny Yarmus, Robert J Lentz, Fabien Maldonado, Interventional Pulmonary Outcomes Group   +14 more
doaj   +1 more source

Ethical issues in implementation research: a discussion of the problems in achieving informed consent [PDF]

, 2008
Background: Improved quality of care is a policy objective of health care systems around the world. Implementation research is the scientific study of methods to promote the systematic uptake of clinical research findings into routine clinical practice ...
A Iversen, A Vahratian, American Statistical Association, B Briesacher, B Woodward, C Junghans, C Verity, Council of the International Organisation of Medical Sciences, D Raffe, H Ward, International Statistical Institute, J Grimshaw, J Tu, Jane L Hutton, Jeremy M Grimshaw, JL Hutton, JL Hutton, L Doyal, M Eccles, M Eccles, M Eccles, M Robling, M Thompson, Martin P Eccles, MP Eccles, MRC ethics series, R Baker, R Foy, R Grol, R Winkelmann, RE Ashcroft, RE Ashcroft, Royal Statistical Society, S Blackstone, S Rogerson, S Woolf, SJL Edwards, T Beauchap, T Walley, World Medical Association Declaration of Helsinki   +39 more
core   +3 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Methods in the design and implementation of the Randomized Evaluation of Sedation Titration for Respiratory Failure (RESTORE) clinical trial

Trials, 2018
Background Few papers discuss the pragmatics of conducting large, cluster randomized clinical trials. Here we describe the sequential steps taken to develop methods to implement the Randomized Evaluation of Sedation Titration for Respiratory Failure ...
Martha A. Q. Curley, Rainer G. Gedeit, Brenda L Dodson, June K. Amling, Deborah J. Soetenga, Christiane O. Corriveau, Lisa A. Asaro, David Wypij, For the RESTORE Investigative Team   +8 more
doaj   +1 more source

Neuromodulation [PDF]

, 2016
Neuromodulation is a new promising treatment for headache disorders. It consists of peripheral nerve neurostimulation and central neurostimulation. © 2016, Touch Briefings.
Silberstein, Stephen
core   +2 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Choosing an imbalance metric for covariate-constrained randomization in multiple-arm cluster-randomized trials

Trials, 2019
Background In cluster-randomized controlled trials (C-RCTs), covariate-constrained randomization (CCR) methods efficiently control imbalance in multiple baseline cluster-level variables, but the choice of imbalance metric to define the subset of ...
Jody D. Ciolino, Alicia Diebold, Jessica K. Jensen, Gerald W. Rouleau, Kimberly K. Koloms, Darius Tandon   +5 more
doaj   +1 more source

Access to HIV care in the context of universal test and treat: challenges within the ANRS 12249 TasP cluster-randomized trial in rural South Africa [PDF]

, 2016
Introduction: We aimed to quantify and identify associated factors of linkage to HIV care following home-based HIV counselling and testing (HBHCT) in the ongoing ANRS 12249 treatment-as-prevention (TasP) cluster-randomized trial in rural KwaZulu-Natal ...
Attia, Barnabas, Bassett, Cohen, Collins Iwuji, Danel, Doherty, Donnell, Fox, France Lert, François Dabis, Granich, Hatcher, Houlihan, Iwuji, Joanna Orne-Gliemann, Joseph Larmarange, Kamal El Farouki, Lundgren, MacPherson, Maheswaran, Marie-Louise Newell, Medley, Morris, Mugglin, Muloongo, Mélanie Plazy, Naik, Naik, Nakigozi, Nonhlanhla Okesola, Nsigaye, Orne-Gliemann, Rooyen, Rosemary Dray-Spira, Rosen, Tabana, Tanser, Wringe, Zaidi   +39 more
core   +6 more sources