Results 71 to 80 of about 1,420,828 (341)

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

rEMM: Extensible Markov Model for Data Stream Clustering in R

open access: yesJournal of Statistical Software, 2010
Clustering streams of continuously arriving data has become an important application of data mining in recent years and efficient algorithms have been proposed by several researchers. However, clustering alone neglects the fact that data in a data stream
Michael Hahsler, Margaret H. Dunham
doaj  

The power of microRNA regulation—insights into immunity and metabolism

open access: yesFEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto   +2 more
wiley   +1 more source

Customer Segmentation Based on the Electricity Demand Signature: The Andalusian Case

open access: yesEnergies, 2018
A smart meter enables electric utilities to get detailed insights into their customer needs, allowing them to offer tailored products and services, and to succeed in an increasingly competitive market.
Andrés Camero   +3 more
doaj   +1 more source

Towards combinatorial clustering: preliminary research survey [PDF]

open access: yesarXiv, 2015
The paper describes clustering problems from the combinatorial viewpoint. A brief systemic survey is presented including the following: (i) basic clustering problems (e.g., classification, clustering, sorting, clustering with an order over cluster), (ii) basic approaches to assessment of objects and object proximities (i.e., scales, comparison ...
arxiv  

Optical and X-ray clusters as tracers of the supercluster-void network. I Superclusters of Abell and X-ray clusters [PDF]

open access: yes, 2000
We study the distribution of X-ray selected clusters of galaxies with respect to superclusters determined by Abell clusters of galaxies and show that the distribution of X-ray clusters follows the supercluster-void network determined by Abell clusters. We find that in this network X-ray clusters are more strongly clustered than other clusters.
arxiv   +1 more source

Convex Clustering through MM: An Efficient Algorithm to Perform Hierarchical Clustering [PDF]

open access: yesarXiv, 2022
Convex clustering is a modern method with both hierarchical and $k$-means clustering characteristics. Although convex clustering can capture complex clustering structures hidden in data, the existing convex clustering algorithms are not scalable to large data sets with sample sizes greater than several thousands.
arxiv  

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

open access: yesFEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Cluster-based Dynamic Energy Management for Collaborative Target Tracking in Wireless Sensor Networks

open access: yesSensors, 2007
A primary criterion of wireless sensor network is energy efficiency. Focused onthe energy problem of target tracking in wireless sensor networks, this paper proposes acluster-based dynamic energy management mechanism. Target tracking problem isformulated
Dao-Wei Bi   +3 more
doaj   +1 more source

Clusters and entrepreneurship [PDF]

open access: yesJournal of Economic Geography, 2010
This article examines the role of regional clusters in regional entrepreneurship. We focus on the distinct influences of convergence and agglomeration on growth in the number of start-up firms as well as in employment in these new firms in a given region-industry.
Mercedes Delgado   +3 more
openaire   +7 more sources

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