Results 51 to 60 of about 2,690,463 (245)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
DDG-clustering: a novel technique for highly accurate results [PDF]
, 2009 A key to the success of any clustering algorithm is the similarity measure applied. The similarity among different instances is defined according to a particular criterion.
Gaber, Mohamed Medhat +3 more
core
Abstract and Applied Analysis, 2014 Owing to the increase and the complexity of data caused by the uncertain environment, the water environment monitoring system in Three Gorges Reservoir Area faces much pressure in data handling.
Yuanchang Zhong +4 more
doaj +1 more source
An Algorithmic Introduction to Clustering
CoRR, 2020 This paper tries to present a more unified view of clustering, by identifying the relationships between five different clustering algorithms. Some of the results are not new, but they are presented in a cleaner, simpler and more concise way. To the best of my knowledge, the interpretation of DBSCAN as a climbing procedure, which introduces a ...
openaire +3 more sources
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
A K-means Algorithm Based On Feature Weighting
MATEC Web of Conferences, 2018 Cluster analysis is a statistical analysis technique that divides the research objects into relatively homogeneous groups. The core of cluster analysis is to find useful clusters of objects.
Xu Yan +4 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Applied Sciences, 2021 K-means clustering algorithm is a partitional clustering algorithm that has been used widely in many applications for traditional clustering due to its simplicity and low computational complexity.
Abiodun M. Ikotun +2 more
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source