Results 101 to 110 of about 1,846,894 (263)
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Determine the Climatic Seasons of Zahedan by the use of Cluster Analysis Method Dr. Hamid Nazaripour Assistant Professor of Climatology, Science International Centre, Advanced Technology and Environmental Sciences, Kerman Dr. Rashid. Saieed Abadi Assistant Professor of Climatology University of Oromieh [PDF]
جغرافیا و توسعه, 2012 Introduction Changeability is one of the characteristics of climatology, and natural seasons unlike the calendar seasons are variable. Therefore, natural seasons have time- spatial changes.
doaj +1 more source
YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
Frontiers in EndocrinologyIntroductionChildhood obesity is a growing global health concern, but few studies have investigated dietary factors specifically related to obesity and abdominal obesity in children and adolescents.
Ye-Jin Yun +5 more
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Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source
A clustering-based repeating earthquakes identification method and its application
地球与行星物理论评Events with highly similar waveforms and rupturing of the same fault patch are interpreted as repeating earthquakes, which can be applied in detecting deep fault deformation, characterizing fault behavior, and assess seismic hazards.
Yafen Huang +4 more
doaj +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Annual Daily Irradiance Analysis of Clusters in Mexico by Machine Learning Algorithms
Remote SensingThe assessment of solar resources involves the utilization of physical or satellite models for the determination of solar radiation on the Earth’s surface.
Jared D. Salinas-González +7 more
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Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source