Results 161 to 170 of about 1,846,894 (263)

Spatial accessibility evaluation and clustering analysis of primary healthcare within 15 min circles in a northern Chinese megacity. [PDF]

Sci Rep
Han J, Fu L, Zhang X, Pei T, Long H.
europepmc   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Different phenotypes of severe flares in patients with systemic lupus erythematosus: results of a clustering analysis in a monocentric cohort. [PDF]

Front Immunol
Elefante E, Schilirò D, Manca ML, Stagnaro C, Zucchi D, Cardelli C, Signorini V, Maffi M, Cascarano G, Zas R, Carli L, Ferro F, Tani C, Mosca M.   +13 more
europepmc   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

Unbiased cell clustering analysis of vaccine-induced T cell responses in the Imbokodo HIV-1 vaccine trial. [PDF]

EBioMedicine
Voillet V, van Duijn J, Vanshylla K, Dintwe OB, Pattacini L, Omar FL, Khuzwayo S, Euler Z, Schwedhelm K, MacMillan HR, Gilbert PB, Fiore-Gartland A, Newell EW, Hendriks J, McElrath MJ, Stieh DJ, De Rosa SC, Andersen-Nissen E.   +17 more
europepmc   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Structure-guided integrative soft deep clustering analysis of scRNA-seq and scATAC-seq data. [PDF]

Front Microbiol
Xingzuo J, Chenyuan W, Jiaxi Y, Chengyuan W.   +3 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Identifying Risk Groups in 73,000 Patients with Diabetes Receiving Total Hip Replacement: A Machine Learning Clustering Analysis. [PDF]

J Pers Med
Ahmadi A, Kaywood AJ, Chavarria A, Omobhude OF, Kiss A, Faltyn M, Hoellwarth JS.   +6 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source